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A six year old child with recurrent and multiple lesions of pyoderma gangrenosum is reported. The disease was resistant to conventional modalities of treatment. He was treated with pulse therapy in the form of 32 mg dexamthasone in 200 ml of 5% glucose by slow intravenous drip on two consecutive days. The pulses were repeated at two week intervals. Five such pulses led to complete and sustained healing of all the lesions.