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Fifteen very fair women with mild to moderate photoaging in there 60’s were tested by doubled blind immunohistological study. Tretinoin 0.05% cream applied daily was compared to its vehicle with regards to epidermal, basal, spinous differentiation markers and dendritic cells (Langerhan’s and melariocyte). In comparison with the control skin, tretinoin-treated skin showed the following changes: 1. From atrophy to normalization or hyperplasia of horny and prickle cell layers,2. Granular layer was normal to hypertrophied, 3. Basal cells were well-stained and thicker, 4. Basement membrane was thicker to normal in appearance and 5. Dendritic cells were increased in number (Langerhan’s). These results demonstrated a decelerating effect of tretinoin on the time clock of photoaging.
