Source of Support: None, Conflict of Interest: None
Forty Patients of Xanthelasma palpebrarum (XP) and forty age & sex related controls were collected form the skin OPD of N R S Medical College Hospital and put to clinical and biochemical examinations. XP was found to be more prevalent among female (67.5%) than in male (32.5%). Majority (55%) of the patients belonged to 31-50 years age group in both the sexes. Family history of XP was found in significantly more number of patients (27.5%) than in controls (0%). Family history of diabetes, ischemic heart disease, and hypertension was detected in 20%, 32.5% and 20% of patients respectively and no significant difference was seen from the control. Arcus senilis was detected in25% patients. Forty percent patients were hypercholesterolaemic among which 27.5%. Patients had cholesterol level> 240mg/df whereas 5% controls had the level between 200-240mg/df. Hypertiglyceridaemia was present in 22.5% patients and 5% controls. LDL cholesterol elevation was found in more than30% cases and only slightly elevated in 5% controls. HDL Cholesterol level was below normal in 15% patients and none among control. Overall, 52.5% patients had some form of abnormal lipid profile and only 10% control had the same problem. This difference was statistically highly significant (p<0.001). Electrocardiography was abnormal in 22.5% patients and 5% controls and the difference was significant (p<0.02). Blood sugar level was normal in both the study & the control groups.