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The case of a 58 year old man who developed a well-differentiated squamous cell carcinoma (SCC) in a pre-existing plaque of lichen planus hypertrophicus (LPH) is reported. The LPH lesions were confined to the anterior aspect of legs for 34 years before the development of SCC in one of the larger plaques. Although reported in the literature, the malignant transformation of cutaneous lichen planus is a rare occurrence. The SCC was treated with complete excision and the defect was closed with an autograft taken from the thigh.