IJD
Indian Journal of Dermatology
  Publication of IADVL, WB
  Official organ of AADV
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Year : 1994  |  Volume : 39  |  Issue : 2  |  Page : 19-21

A new intralesional therapy of cutaneous leishmaniasis with hypertonic sodium chloride solution.


Department of Dermatology, College of Medicine, University of Baghdad, Bab-Al Moadham, P.O. Box 14321, Baghdad, Iraq

Correspondence Address:
KE Sharquie
Department of Dermatology, College of Medicine, University of Baghdad, Bab-Al Moadham, P.O. Box 14321, Baghdad
Iraq
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Source of Support: None, Conflict of Interest: None


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ABSTRACT: One hundred and fifty eight lesions of acute cutaneous leishmaniasis in 70 patients were treated with hypertonic sodium chloride solution (88 lesions), pentostam (50 lesions) and 20 lesions were left untreated as controls. The injections were given at 7-10 day intervals and patients were followed-up for 42 days. Hypertonic sodium chloride solution was shown to be very effective local therapy (96 percent cure rate) and was as effective as local pentostam (96.4 percent cure rate). In both types of therapy most lesions needed one injection. Mild improvement was noticed after 7-10 days of the first injection while the cure was noticed within 2-6 weeks (mean 4 weeks) of follow up. None of the control lesions showed a cure within the 6 weeks follow-up. The mechanism of action of both local hypertonic sodium chloride and sodium stibogluconate (pentostam) is probably through interfering with osmotic pressure of cell cytoplasm of the parasites and the lesional tissues. Scarring was either absent or minimal following healing of the treated lesions in both types of treatment. Post-inflammatory hyperpigmentation was observed in all patients. We strongly recommend intralesional hypertonic sodium chloride as a cheap, safe, and effective method of treating cutaneous leishmaniasis.


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