Indian Journal of Dermatology
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Year : 1991  |  Volume : 36  |  Issue : 2  |  Page : 54-58

Interferon alpha-2b in genital warts

Department of Dermatology & STD Calcutta National Medical College & Hospital Calcutta

Correspondence Address:
SK Panja
Department of Dermatology & STD Calcutta National Medical College & Hospital Calcutta

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Source of Support: None, Conflict of Interest: None

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ABSTRACT: A clinical study is undertaken to evaluate the effectiveness of Interferon (IFN) alpha-2b (rbe) in genital warts. This IFN alpha-2b is produced from bacteria (Escherichia coli) genetically modified by recombinant DNA technology. The treatment schedule consists of the subcutaneous injection of 1x10 6 I.U. IFN alpha-2b 3 times weekly perilesionally. Therapy is given for 10 injections. In some patients the course is repeated and is some upto 2x10 6 I.U. IFN is given in one sitting. All patients are evaluated with reference to age, sex, site, number and size of the lesions, The injection is tolerated well by the patients and none of them show side effects like flu like syndrome with nausea and vomiting, altered liver and renal functions, cardiovascular complications, neurological abnormalities and bone marrow depression. The results are very much encouraging and complete clearance of the warts to excellent response occurred in all patients. In some, even adjacent warts which are not injected also show signs of resolution and clearing. It is concluded that interferon alpha-2b is a very useful therapy for genital warts.

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