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Figure 1: Pemphigus vulgaris shows extensive acantholytic cells in the bullous cavity (a; H and E, ×400). Immunoglobulin G4 immunoreactivity with distinct continuous pattern localized to intercellular junction of the keratinocytes in both sides of the blister is obvious (b; immunohistochemistry, ×400). Immunohistochemistry findings are compatible direct immunofluorescence by immunoglobulin G4 (c; direct immunofluorescence, ×400). Pemphigus vulgaris shows in low power (d; H and E, ×100). Lace-like pattern immunoreactivity for immunoglobulin G4 is very distinct and comparable with direct immunofluorescence (e; immunohistochemistry, ×400 and f; direct immunofluorescence, ×400)

Figure 1: Pemphigus vulgaris shows extensive acantholytic cells in the bullous cavity (a; H and E, ×400). Immunoglobulin G4 immunoreactivity with distinct continuous pattern localized to intercellular junction of the keratinocytes in both sides of the blister is obvious (b; immunohistochemistry, ×400). Immunohistochemistry findings are compatible direct immunofluorescence by immunoglobulin G4 (c; direct immunofluorescence, ×400). Pemphigus vulgaris shows in low power (d; H and E, ×100). Lace-like pattern immunoreactivity for immunoglobulin G4 is very distinct and comparable with direct immunofluorescence (e; immunohistochemistry, ×400 and f; direct immunofluorescence, ×400)