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Figure 5: The expression of Bcl2, Bax, Caspase 3, and Caspase 9 affected by vascular endothelial growth factor, semaphorin 3A, and acitretin. The alternative mRNA expression of Bcl2, Bax, Caspase 3, and Caspase 9 tested by reverse transcription-polymerase chain reaction assay in different groups. When compared with the control group and vascular endothelial growth factor group, both semaphorin 3A and acitretin reduced the expression of Bcl2 and increased the expression of Bax, Caspase 3, and Caspase 9. Semaphorin 3A and acitretin reduced the expression of vascular endothelial growth factor (P = 0.009 and P = 0.006, respectively) compared to the vascular endothelial growth factor group. *P < 0.05, **P < 0.005 versus control group. #P < 0.05, ##P < 0.005 versus vascular endothelial growth factor exposed groups

Figure 5: The expression of Bcl2, Bax, Caspase 3, and Caspase 9 affected by vascular endothelial growth factor, semaphorin 3A, and acitretin. The alternative mRNA expression of Bcl2, Bax, Caspase 3, and Caspase 9 tested by reverse transcription-polymerase chain reaction assay in different groups. When compared with the control group and vascular endothelial growth factor group, both semaphorin 3A and acitretin reduced the expression of Bcl2 and increased the expression of Bax, Caspase 3, and Caspase 9. Semaphorin 3A and acitretin reduced the expression of vascular endothelial growth factor (<i>P</i> = 0.009 and <i>P</i> = 0.006, respectively) compared to the vascular endothelial growth factor group. *<i>P</i> < 0.05, **<i>P</i> < 0.005 versus control group. <sup>#</sup><i>P</i> < 0.05, <sup>##</sup><i>P</i> < 0.005 versus vascular endothelial growth factor exposed groups