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Figure 3: Presentation of the drug bound to major histocompatibility complex Class II by keratinocytes to CD4 cells resulting in (a) the release of CXC chemokine ligand 8 and granulocyte–macrophage colony-stimulating factor by both CD4 cells and keratinocytes which lead to (b) the migration of neutrophils into the epidermis and the conversion of the subcorneal blister into a sterile pustule. TCR: T-cell receptor.

Figure 3: Presentation of the drug bound to major histocompatibility complex Class II by keratinocytes to CD4 cells resulting in (a) the release of CXC chemokine ligand 8 and granulocyte–macrophage colony-stimulating factor by both CD4 cells and keratinocytes which lead to (b) the migration of neutrophils into the epidermis and the conversion of the subcorneal blister into a sterile pustule. TCR: T-cell receptor.