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Figure 1: Fixed - effects models (a) assume that each trial represents a random sample (colored curves) of a single population with a single response to treatment. Random - effects models (b) assume that the different trials' results (colored curves) may come from different populations with varying responses to treatment.

Figure 1: Fixed - effects models (a) assume that each trial represents a random sample (colored curves) of a single population with a single response to treatment. Random - effects models (b) assume that the different trials' results (colored curves) may come from different populations with varying responses to treatment.