Indian Journal of Dermatology
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   2012| March-April  | Volume 57 | Issue 2  
    Online since April 20, 2012

 
 
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REVIEW ARTICLE
The concept of stability of vitiligo: A reappraisal
Koushik Lahiri, Subrata Malakar
March-April 2012, 57(2):83-89
DOI:10.4103/0019-5154.94271  PMID:22615501
Stability is taken as the most important parameter before opting for any transplantation technique to treat vitiligo. But, simultaneous donor site repigmentation and depigmentation of grafts at the recipient site has been noted. Similarly donor site depigmentation with complete repigmentation of the recipient area with pigment growing out from each graft has been observed. Successful repigmentation after regrafting in previous punch failure cases has also been reported. Koebner's phenomenon from history (Kp-h) and test grafting were the only available indicators to assess stability. It is quite ironic to note that even after four decades of experience in vitiligo surgery, there seems to be little consensus among workers regarding the optimal required period of stability. Moreover, the exact concept of stability in vitiligo is itself still not transparent and defined beyond doubt Overdependence on KpH or TG may be sometimes misleading in vitiligo. These two reveal the apparent clinical stability only and that may not be the true reflection of stability status of the disease at the molecular level. Antimelanocyte cytotoxic reactivity was observed among CD8+ TCC isolated from perilesional biopsies of patients with vitiligo. An attempt should be made to clearly fathom and define stability, not merely only on clinical ground but along with electron microscopy and histoenzymological analysis of the perilesional and nonlesional skin of vitiligo patients. Probably some growth factors which are responsible for both mitogenic and melanogenic stimulation of melanocytes should also be taken into account. Some serological test(s) could guide us to measure these growth factors.
  8,039 345 3
CASE REPORTS
Secondary lymphangioma of vulva: A report of two cases
Pushpa Gnanaraj, V Revathy, V Venugopal, D Tamilchelvan, V Rajagopalan
March-April 2012, 57(2):149-151
DOI:10.4103/0019-5154.94293  PMID:22615519
Secondary lymphangiomas or acquired lymphangiomas of vulva represent dilatation of upper dermal lymphatics following damage to previously normal deep lymphatics. They have been reported to occur following various infections, surgeries and radiotherapy which can cause damage to deep lymphatics.Treatment options in the management of secondary lymphangiomas include surgical resection, carbon dioxide laser vaporisation, sclerosing agents etc. We report two cases of secondary lymphangioma of vulva that followed radiotherapy for carcinoma of cervix. Both the patients were treated successfully by surgery.
  7,734 62 1
Recurrent facial urticaria following herpes simplex labialis
Vijay Zawar, Kiran Godse
March-April 2012, 57(2):144-145
DOI:10.4103/0019-5154.94290  PMID:22615517
We describe recurrent acute right-sided facial urticaria associated with herpes labialis infection in a middle-aged female patient. Antiviral medications and antihistamines not only successfully cleared the herpes infection and urticaria but also prevented further recurrences.
  5,306 73 1
DERMATOPATHOLOGY ROUND
A retrospective analysis of histopathology of 64 cases of lepra reactions
Vijay Adhe, Atul Dongre, Uday Khopkar
March-April 2012, 57(2):114-117
DOI:10.4103/0019-5154.94278  PMID:22615507
Background: Lepra reactions are not always diagnosable under the microscope. We analyzed skin histopathology in 64 cases of lepra reaction. Aim : To make detailed observations on histopathologic features of type 1 and type 2 lepra reaction (erythema nodosum leprosum, ENL). Materials and Methods : In this retrospective study, we included 64 patients diagnosed during a 3-year period as lepra reaction based on clinico-pathological co-relation. Results : Out of the 64 patients, 22 were of type 1 reaction and 42 of ENL. The most consistent finding in type 1 reaction was papillary dermal edema (86%) followed by pyknosis of lymphocytes (77%) and intercellular edema within granuloma (73%). Surprisingly, folliculotropism of lymphocytes was seen in 55% and subcutaneous infiltration in 36%. In ENL, the most common finding was presence of neutrophils within the granuloma (100%), followed by leukocytoclasia (81%), papillary dermal edema (81%), and neutrophilic panniculitis (69%). Fibrin in the vessel wall or/and granulomas was noted in only 38% while fibrin thrombi in the vessel walls were seen in only 12% of cases. Conclusion: Infiltration of macrophage granulomas by neutrophils is a reliable sign of ENL. Classical signs of vasculitis are not always present in ENL. Folliculotropism and lymphocytic panniculitis were frequent in type 1 reactions while neutrophilic panniculitis was common with ENL.
  4,559 189 5
CASE REPORTS
Unilateral nevoid telangiectasia: A rare disease?
Rita Guedes, L Leite
March-April 2012, 57(2):138-140
DOI:10.4103/0019-5154.94288  PMID:22615515
Unilateral nevoid telangiectasia is a rare congenital or acquired disorder. The majority of the authors propose that it is probably related to elevated estrogen receptors, although other authors advocate different theories. We report the occurrence of lesions clinically compatible with this diagnosis in a child and two adults. Only one of the patients had a background of estrogen elevation. The other two patients were healthy. We stress the occurrence of this disease in a rare idiopathic form and point out to the relative elevated incidence of it, because the patients discussed in this article were observed for a short period of time.
  4,407 58 2
DERMATOSURGERY ROUND
Comparison of red and infrared low-level laser therapy in the treatment of acne vulgaris
Mir Hadi Aziz-Jalali, Seyed Mehdi Tabaie, Gholamreza Esmaeeli Djavid
March-April 2012, 57(2):128-130
DOI:10.4103/0019-5154.94283  PMID:22615511
Background/Purpose : Acne vulgaris is a very prevalent skin disorder and remains a main problem in practice. Recently, phototherapy with various light spectrums for acne has been used. There are some evidences that low-level laser therapy (LLLT) has beneficial effect in the treatment of acne lesions. In this study, two different wavelengths of LLLT (630 and 890 nm) were evaluated in treatment of acne vulgaris. Materials and Methods: This study was a single-blind randomized clinical trial. Patients with mild to moderate acne vulgaris and age above 18 years and included were treated with red LLLT (630 nm) and infrared LLLT (890 nm) on the right and left sides of the face respectively, twice in a week for 12 sessions, and clinically assessed at baseline and weeks 2, 4, 6, and 8. Results: Twenty-eight patients were participated in this study. Ten weeks after treatment acne lesion were significantly decreased in the side treated by 630 nm LLLT (27.7±12.7 to 6.3±1.9) (P<0.001), but this decrease was not significant in the site treated by 890 nm LLLT (26.9±12.4 to 22.2±8.5) (P>0.05). Conclusion: Red wavelength is safe and effective to be used to treat acne vulgaris by LLLT compared to infrared wavelength.
  4,143 85 1
SPECIAL ARTICLE
The role of cytokines in the pathomechanism of cutaneous disorders
Arijit Coondoo
March-April 2012, 57(2):90-96
DOI:10.4103/0019-5154.94272  PMID:22615502
Cytokines are produced transiently by cutaneous cells in response to immune stimuli. They are non-immunoglobulin proteins and glycoproteins. Cytokines, which are signaling molecules, act by sending downstream signals to various cells through a number of signal transduction pathways and by binding to cytokine receptors on the surface of cells. Cytokines regulate immunity and inflammation and thus play an important role in the pathogenesis of various cutaneous disorders.
  3,708 262 1
ORIGINAL ARTICLES
Prevalence of oral, skin, and oral and skin lesions of lichen planus in patients visiting a dental school in Southern India
PM Omal, Vimal Jacob, Akhilesh Prathap, Nebu George Thomas
March-April 2012, 57(2):107-109
DOI:10.4103/0019-5154.94276  PMID:22615505
Background: Lichen planus (LP) is a mucocutaneous disease that is relatively common among adult population. LP can present as skin and oral lesions. This study highlights the prevalence of oral, skin, and oral and skin lesions of LP. Aims: The aim of this study was to evaluate the prevalence of oral, skin, and oral and skin lesions of LP from a population of patients attending the Department of Oral Medicine and Radiodiagnosis, Pushpagiri College of Dental Sciences, Tiruvalla, Kerala, India. Materials and Methods: A cross-sectional study was designed to evaluate the prevalence of oral, skin, and oral and skin lesions of LP. This is a ongoing prospective study with results of 2 years being reported. LP was diagnosed on the basis of clinical presentation and histopathological analysis of mucosal and skin biopsy done for all patients suspected of having LP. Statistical analysis was carried out using SPSS (Statistical package for social sciences) software version 14. To test the statistical significance, chi-square test was used. Results: Out of 18,306 patients screened, 8,040 were males and 10,266 females. LP was seen in 118 cases (0.64%). Increased prevalence of LP was observed in middle age adults (40-60 years age group) with lowest age of 12 years and highest age of 65 years. No statistically significant differences were observed between the genders in skin LP group (P=0.12) and in oral and skin LP groups (P=0.06); however, a strong female predilection was seen in oral LP group (P=0.000036). The prevalence of cutaneous LP in oral LP patients was 0.06%. Conclusion: This study showed an increased prevalence of oral LP than skin LP, and oral and skin LP with a female predominance.
  3,637 169 2
CORRESPONDENCE
Disseminated discoid lupus erythematosus leading to squamous cell carcinoma
M Ramesh Bhat, Manjunath Hulmani, Sukumar Dandakeri, Srinath M Kambil, Rohan Gatti
March-April 2012, 57(2):158-161
DOI:10.4103/0019-5154.94298  PMID:22615523
  3,512 74 -
THERAPEUTIC ROUNDS
Comparison of intralesional two percent zinc sulfate and glucantime injection in treatment of acute cutaneous leishmaniasis
Masoud Maleki, Gholamreza Karimi, Mohsen Tafaghodi, Somayyeh Raftari, Yalda Nahidi
March-April 2012, 57(2):118-122
DOI:10.4103/0019-5154.94279  PMID:22615508
Introduction: Cutaneous leishmaniasis is an endemic disease in developing countries caused by different species of leishmania parasite, and if left untreated, it will result in a deformed scar after a relatively long period. Although various systemic and topical treatments have been proposed for leishmaniasis, pentavalent Antimony compounds remain the first-line treatment for it. Considering the cases with treatment failure, potential side effects and reluctance of patients to receive the drug, there are continuing efforts to find better treatment alternatives. Aim: Comparison of the effect of intralesional 2% zinc sulfate injection with Glucantime in treatment of acute cutaneous leishmaniasis. Materials and Methods: In this clinical trial, 45 patients with clinical diagnosis of cutaneous leishmaniasis and positive direct smear for leishman body were treated by intralesional injection of either 2% zinc sulfate or Glucantime. After simple randomization, in one group the patients were treated with 2 bouts of intralesional 2% zinc sulfate with a 2-week interval, and in the other group they were treated with 6 weekly bouts of intralesional Glucantime. The patients were monitored in two week intervals for 8 weeks. Healing of the lesions was evaluated clinically and by direct smear, and the data were analyzed using SPSS (11.5) software, t-Student, Mann-Whitney and Analysis of covariance (ANCOVA) statistical tests. Findings: In the end of study, 34 patients completed the study, 10 of whom received intralesional Glucantime and 24 of whom received intralesional 2% zinc sulfate. The healing rate after 8 weeks was 80% in the group receiving intralesional Glucantime and 33.3% in the one receiving 2% zinc sulfate (P=0.009). Conclusion: Based on the results of this study, intralesional injection of 2% zinc sulfate was less effective in treatment of cutaneous leishmaniasis than intralesional Glucantime.
  3,394 67 1
CASE REPORTS
Blastomycosis presenting as solitary nodule: A rare presentation
Ashish Dhamija, Paschal D'Souza, Priti Salgia, Ashok Meherda, Rajkumar Kothiwala
March-April 2012, 57(2):133-135
DOI:10.4103/0019-5154.94285  PMID:22615513
Blastomycosis is a chronic granulomatous and suppurative mycosis, caused by Blastomyces dermatitidis, which in the great majority of cases presents as a primary pulmonary disease. Primary cutaneous blastomycosis is very rare. We present a 57-year-old female patient with a solitary, slowly progressive nodule over upper lip of 2½ months duration. Initially, differential diagnosis of cutaneous leishmaniasis, pyoderma and deep mycoses were entertained. Slit smear preparation was suspicious of deep mycotic infection which was subsequently confirmed by biopsy and culture.
  3,182 77 1
CORRESPONDENCE
Reed's syndrome
K Pradeep Srivastava, AK Bajaj
March-April 2012, 57(2):156-157
DOI:10.4103/0019-5154.94296  PMID:22615521
  3,085 61 1
SHORT COMMUNICATION
Limits of fine-needle aspiration cytology in diagnosing pilomatrixoma: A series of 25 cases with clinico-pathologic correlations
A Ieni, P Todaro, AM Bonanno, F Catalano, A Catalano, Giovanni Tuccari
March-April 2012, 57(2):152-155
DOI:10.4103/0019-5154.94295  PMID:22615520
Background: Pilomatrixoma (PMX) is a benign, quite uncommon, skin neoplasm, which is frequently misdiagnosed by clinicians. Aim: We have analyzed 25 PMX to determine the agreement between clinical diagnosis, preoperative FNA characteristics, and corresponding histopathological specimens; moreover, reliable cytologic criteria for PMX and the differential diagnosis to avoid cytological pitfalls have been emphasized. Materials and Methods: By fine-needle aspiration (FNA) cytology a series of consecutive cases of PMX collected during last 5 years were studied. Smears were stained by Papanicolau and May-Grünwald-Giemsa. Results: Patients affected by PMX were 11 males, 14 females (ratio 1:1.27); the mean age was 32.72 years with age range 3-78 years, being 72% (18/25) of patients 40 years or less. PMX was mainly distributed in the head-neck region (52%), scalp (16%), upper/lower arms (28%), and chest (4%). The observed diagnostic cytological features were represented by clusters of basaloid epithelial cells, shadow or ghost cells, inflammatory background, calcification, and giant cells. Unfortunately, not all these morphological aspects were always disclosed in smears, thus making the cytological preoperative diagnosis questionable and problematic. Conclusions: The experience of a well-trained cytopathologist should distinguish the relevant FNA features in terms of smear background, architecture, and cell morphology. The most dangerous mistake in FNA diagnosis of PMX regards a diagnosis of primary malignant or metastatic cutaneous lesions.
  2,918 63 4
CASE REPORTS
Laptop induced erythema Ab Igne
Sudhir U K Nayak, Shrutakirthi D Shenoi, Smitha Prabhu
March-April 2012, 57(2):131-132
DOI:10.4103/0019-5154.94284  PMID:22615512
Erythema ab igne is a reticular, pigmented dermatosis caused by prolonged and repeated exposure to infrared radiation that is insufficient to produce a burn. The use of laptop computers has increased manifold in the recent past. Prolonged contact of the laptop with the skin can lead to the development of erythema ab igne. We present a case of erythema ab igne secondary to laptop use in an Indian student.
  2,804 86 2
Postpartum pemphigoid gestationis
Sumi Thomas, Uma Rajan, Sandhya George, Mamatha George
March-April 2012, 57(2):146-148
DOI:10.4103/0019-5154.94291  PMID:22615518
Pemphigoid gestationis (PG) or herpes gestationis is a rare autoimmune subepidermal blistering disorder associated with pregnancy. The condition typically develops during the second or third trimester of pregnancy, but has been rarely reported in the first trimester and postpartum period. Here, we report a case of PG that presented for the first time in the postpartum period, associated with a low birth weight baby.
  2,773 69 2
THERAPEUTIC ROUNDS
Treatment of cutaneous lesion of 20 years' duration caused by leishmanization
Ali Khamesipour, Azam Abbasi, Alireza Firooz, Akram Mir Amin Mohammadi, Seyed Ebrahim Eskandari, Mahmoud R Jaafari
March-April 2012, 57(2):123-125
DOI:10.4103/0019-5154.94280  PMID:22615509
The inoculation of live Leishmania (L.) major to produce a single lesion is called leishmanization (LZ). LZ lesion upon cure prevents further natural infection which might be multiple lesions on unwanted sites such as face. Cutaneous leishmaniasis (CL) usually leads to a self healing lesion; though rarely the lesion persists and becomes refractory to all types of remedies. Here, we present a 41-year-old patient with a 20-year history of cutaneous lesion caused by leishmanization. The causative agent is identified as L. major. The patient did not respond to treatment with meglumine antimoniate, 20 mg/kg/day Sb +5 for three weeks and allopurinol 10 mg/kg for four weeks. After two months, the same treatment was repeated. In addition, a topical liposomal preparation containing 10% paromomycin sulfate was administered twice a day for four weeks. The lesion showed marked improvement during the treatment and was eventually completely healed.
  2,763 45 -
CASE REPORTS
Solitary cylindroma with malignant transformation
Cherry Bansal, Mayanka Batra, Nirupma Lal, AN Srivastava
March-April 2012, 57(2):141-143
DOI:10.4103/0019-5154.94289  PMID:22615516
A 59-year-old woman presented with a history of rapidly progressive recurrent tumor of 6.5 cm diameter of the scalp. Histopathological examination revealed a case of malignant cylindroma. There has been no recurrence or metastases and the patient is disease free at the end of 15 months postoperatively. Malignant transformation occurs less often in solitary form of cylindroma, but once transformed, tumors behave aggressively with extensive local infiltrative growth or metastases. The case is reported to document a rare case of malignant cylindroma arising in a patient with solitary cylindroma on the parieto-temporal region.
  2,714 49 -
CORRESPONDENCE
IFAP syndrome with rickets and normal vitamin D status
Bashir Ahmad Laway, Sawan Kumar Verma, Mir Iftikhar Bashir, Mohd Ashraf Ganie, Shahnaz Ahmad Mir, Sheikh Manzoor Ahmad, Mohd Iqbal Lone
March-April 2012, 57(2):161-163
DOI:10.4103/0019-5154.94299  PMID:22615524
  2,680 56 1
ORIGINAL ARTICLES
The impact of chronic urticaria on the quality of life in Indian patients
AV Pherwani, G Bansode, S Gadhia
March-April 2012, 57(2):110-113
DOI:10.4103/0019-5154.94277  PMID:22615506
Backgound : Besides the relief of symptoms, the main purpose of any treatment must be to ensure a better quality of life (QOL). Mere recording of symptoms reveals their severity and frequency, but gives scant information on its effect on QOL. Aim: The study was designed to assess QOL in Indian patients with chronic urticaia (CU). Subjects and Methods: We used the validated CU-QOL by Bairadani et al., consisting of five domains and each domain consisting of several items. Each item was scored from 1 to 5 (score 5 = most affected, score 1 = not affected). Criteria for Inclusion: Patients having symptoms of rash and pruritis on most of the days for at least 6 weeks were enrolled. Criteria for Exclusion: If the individuals had CU secondary to any other disease, they were excluded. Results: We enrolled 48 patients. The means of the domains, the items, and the frequency of occurrence of an item were tabulated. The highest mean scores were in the domains of symptoms, followed by sleep disturbances, life activities, looks, and limits. The highest mean scores for the items were for pruritis and wheals followed by sleep disturbances, mood changes, nervousness, embarrassment, fatigue, loss of concentration, reduced work, and social relationships. We also observed a significant relationship among individual items. It is possible that they may have an additive effect. Conclusions: Even though CU significantly affected many items, patients were rarely aware of them. There was a significant inter-item correlation, suggesting that items might be aggravating each other. It is important to address the issues regarding QOL along with symptoms for better management of CU.
  2,490 113 -
BASIC RESEARCH
Skin tags and acanthosis nigricans in patients with hepatitis C infection in relation to insulin resistance and insulin like growth factor-1 levels
Omar Soliman El Safoury, Olfat G Shaker, May Mohsen Fawzy
March-April 2012, 57(2):102-106
DOI:10.4103/0019-5154.94275  PMID:22615504
Background: Skin tags (ST) are papillomas commonly found in the neck, axillae of middle-aged and elderly people Aim: Insulin and insulin-like growth factor (IGF-1) levels are affected by hepatitis C virus (HCV) infection and both of them may be implicated in the etiopathogenesis of ST and acanthosis nigricans (AN) through their proliferative and differentiating properties. So, the aim of this work was to evaluate the impact of HCV infection on ST and AN through the estimation of insulin resistance and IGF-1. Materials and Methods: Participants were arranged into four groups: (ST +ve / HCV +ve) 23 subjects, (ST+ / HCV -ve) 19 subjects, (HCV -ve / ST-ve) 20 subjects and (ST-ve /HCV +ve) 22 subjects. Age, ST size, color, number, AN, fasting glucose, fasting insulin, insulin resistance, IGF-1, HCV-antibodies (Ab) were recorded. Results: The mean number of ST in Group 1 was half the number of ST in Group 2 (11.0±9.3 / 22.3±14.0) (P=0.005). The difference in insulin resistance between the same groups was non-significant (13.1±10.6 / 9.0±5.5) (P=0.441) while the difference in IGF-1 was statistically significant (218.6±46.2 /285.4±32.8) (P=0.002). The multivariate logistic regression for the variables revealed that insulin resistance is the only factor affecting the occurrence of ST (OR=1.096, P=0.023). Multivariate regression analysis for the variables showed that HCV was borderline but not a significant factor affecting the number of ST (Beta=-0.409, P=0.053). The number of patients with AN was doubled in Group 2 in comparison to Group 1 but this was non significant 3(13%) / 6(32%) (P=0.2800). Conclusion: HCV is associated with a significant decrease in the ST number and in the serum level of IGF-1 together with an obvious decrease in the occurrence of AN. Our results may point to the entrant effect of insulin resistance and IGF-1 in ST and AN development. The current study suggests the evaluation of IGF-1-lowering agents in the control of ST and AN especially in the females with polycystic ovary and in the prevention of the recurrence of ST after surgical removal.
  2,420 70 2
PHOTO QUIZ
Keratotic papule with a collarette of skin
Keshavmurthy A Adya, Aparna Palit, Arun C Inamadar
March-April 2012, 57(2):164-165
DOI:10.4103/0019-5154.94300  PMID:22615525
  2,326 103 -
CASE REPORTS
Necrodestructive herpes zoster
Sanjeev Gupta, Sunita Gupta, Kamal Aggarwal, Vijay Kumar Jain
March-April 2012, 57(2):136-137
DOI:10.4103/0019-5154.94286  PMID:22615514
Herpes Zoster (HZ) is a self-limiting viral infection of skin and mucosa caused by Varicella zoster virus. Cutaneous lesions of HZ usually heal without any scarring and hyper/hypopigmentation. Though, post-inflammatory depigmentation and deep scarring can occur in immunocompromised or HIV positive individuals. The present report is of a elderly immunocompetent female who had HZ involving the ophthalmic division (including nasociliary branch) of trigeminal nerve. The lesions over nose caused mutilating scarring resulting in complete obstruction of the right anterior nare.
  2,242 62 -
THERAPEUTIC ROUNDS
Variable response to propranolol therapy for infantile hemangiomas
Vishesh Jain, Subhasis Roychoudhury, Rajiv Chadha, Archana Puri
March-April 2012, 57(2):126-127
DOI:10.4103/0019-5154.94281  PMID:22615510
Since propranolol was accidentally discovered to induce involution of hemangiomas, it is being used by many clinicians with a favourable response. We present our experience with use of propranolol and report three infants with hemangiomas who were treated with propranolol. First infant had a marked involution of the lesion; second infant had a appreciable response while the third infant had a initial minimal response with progressive increase in size of the lesion.
  2,093 81 -
BASIC RESEARCH
Serum lipid, lipoprotein and oxidatively modified low density lipoprotein levels in active or inactive patients with behçet's disease
Fuat Cimen, Sembol Turkmen Yildirmak, Andac Ergen, Mustafa Cakmak, Serkan Dogan, Necati Yenice, Funda Sezgin
March-April 2012, 57(2):97-101
DOI:10.4103/0019-5154.94273  PMID:22615503
Aim: To determine serum lipid, lipoproteins and oxidized low density lipoprotein (oxLDL) levels in Behçet's disease (BD) and to evaluate the relationship of these parameters with the clinical activity of the disease. Materials and Methods: Sixty-two patients (25 active, 37 inactive) and -26 healthy controls were included in the study. We measured serum oxLDL levels using the enzyme-linked immunosorbent assay method, and serum total cholesterol (TC), triglyceride (TG) and high density lipoprotein-cholesterol (HDL-C) levels by spectrophotometric method. Results: Serum TG (108±70 mg/dL and 79±40 mg/dL, respectively; P<0.05), LDL-C (124±35 mg/dL and 108±26 mg/dL, respectively; P<0.05) and oxLDL (65±19 U/L and 53±10 U/L, respectively; P<0.01) levels were significantly higher in patients than in controls, but HDL-C levels were significantly lower in patients than in controls (39±11 mg/dL and 50±13 mg/dL, respectively; P<0.05). The levels of oxLDL in patients were found to correlate with those of TC and LDL-C. Neither the lipid parameters nor the oxLDL levels in the patients with active disease (n=25) were different than those in the patients who were in inactive stage (n=37). Serum levels of oxLDL in the patients with active and inactive disease were significantly higher than those in controls (66±19 U/L, 65±19 U/L, and 53±10 U/L, respectively; P<0.05). Conclusions: We conclude that the increase of TG, LDL-C and oxLDL levels and the decrease of HDL-levels may indicate that there is a tendency to atherothrombotic process in patients with BD. Inflammation and immunologic reactions in BD may be caused by a response to elevated oxLDL. TG, LDL-C and oxLDL are not useful markers for the severity of the disease activity.
  1,981 41 -
CORRESPONDENCE
T-cell prolymphocytic leukemia with cutaneous involvement as the presenting feature
Amrut V Ashturkar, Gayatri S Pathak, Yuvraj E More, Ashok Bhandare
March-April 2012, 57(2):157-158
DOI:10.4103/0019-5154.94297  PMID:22615522
  1,920 44 -
BOOK REVIEW
Dermatology jewels: An approach to diagnosis
SR Sengupta
March-April 2012, 57(2):166-166
DOI:10.4103/0019-5154.94301  
  1,740 84 -
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