Indian Journal of Dermatology
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   2004| January-April  | Volume 49 | Issue 1  
    Online since July 20, 2009

 
 
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Dexamethasone-Cyclophosphamide Pulse Therapy In Pemphigus : An Appraisal OF Its Outcome In A Tertiary Health Care Center In South India
Devinder Mohan Thappa, K Karthikeyan, B Jeevankumar
January-April 2004, 49(1):9-13
Dexamethasone-cyclophoshamide pulse (DCP) therapy, designed by Pasricha and Gupta for pemphigus was first used in 1981 with the aim of reducing the toxicity of corticosteroids and also to achieve better therapeutic results. We have been using the same pulse therapy and herewith are presenting the results of pulse therapy in pemphigus were included in the study over a period of 6 years. They consisted of 51 cases of pemphigus vulgaris and 4 cases of pemphigus foliaceous. The male to female ration was 1.2:1. The age distribution showed a bimodal pattern with peaks at 21-30 years and 51-60 years. The body surface area involved at the time of initiation of DCP was less than 25% in 25, 25-50% in 19 and more than 50% in 11 cases. Oral cavity was involved in all cases of pemphigus vulgaris and eyes were affected in 4 patients. Twentysix cases were managed with DCP pulses only and were in remission in phase II and three of our patients in remission in phase III relapsed at 6 to 9 months. Interpulse steroids were required to induce remission in 11 patients. The remaining 18 patients did not proceed to phase II as they was either defaulting or had active disease. Only four cases progressed into phase IV and were declared cured. The various complications seen in our patients were candidiasis (n=5), hiccups (2), acneiform eruption (2), iatrogenic Cushing’s syndrome (1), herpes zoster (1), striae distensae (1), umbilical abscess (1), alopecia (1), azoospermia (1) pneumonia (1) and deep vein thrombosis (1). Two Patients on pulse therapy died of septicemia.
[ABSTRACT]   Full text not available  [PDF]
  2,426 429 -
Study Of Nail Changes In Psoriasis
Astikmoni Ghosal, D N Gangopadhyay, M Chanda, Nilay Kanti Das
January-April 2004, 49(1):18-21
Background: In psoriasis, nail involvement is quite a common phenomenon and the manifestation may range from pitting, Beau’s line, leuconychia, onychorrhexis, onycholysis, subungual hyperkeratosis, thinning of nail plate to less commonly splinter hemorrhage, oil drop sign and salmon patch. Objective: To study overall pattern of nail involvement in psoriatic patients along with making a comparison between the patterns of nail changes on finger and toenails and to analyze the association of nail changes with arthropathy and Koebner’s phenomenon. Subjects and settings: One hundred consecutive cases of psoriasis of all age and both sexes were selected for studying the nail changes, in whom diagnosis of psoriasis was made on clinical parameters. KOH preparation was also performed in all cases where onychomycosis was considered a possibility. Results: Thirty six Percent of patients of psoriasis had nail change and fingernails (32%) were more commonly affected than toe nails (24%). Pitting was found to be the most common manifestation in fingernails (65.63%) with significant difference between fingernails and toenails (p<0.001). The frequency of nail changes in psoriasis with joint pain was 73.33% whereas 29.41% in those without joint pain. Chi-square test with Yates correction for the association of nail changes with joint pain gave p value < 0.005 and for the association of nail changes with koebner’s phenomenon p value <0.05. The frequency of nail changes with Koebner’s phenomenon was 56% whereas in those without koebner’s phenomenon it was 29.33%. Conclustion : Pitting was the most common manifestation in fingernails although in toenails subungual hyperkeratosis was the commonest finding. A very strong association was seen between nail changes and joint pain. Association was also strong between nail changes and Koebner’s phenomenon in psoriasis.
[ABSTRACT]   Full text not available  [PDF]
  1,715 381 -
Nevus Lipomatosus Cutaneus Superficialis
Ram Singh Meena, Ashok Kumar Khare, Sandeep Rana, Ashok Meherda, Paschal D'Souza, Sanjay Purohit
January-April 2004, 49(1):42-43
A case of nevus lipomatosus cutaneus superficialis in a 21 year old male is reported because of rarity of this condition.
[ABSTRACT]   Full text not available  [PDF]
  1,457 69 -
Topical Tacrolimus In Atopic Dermatitis : A Placebo Controlled Study With 15 Children
Sandipan Dhar, Raghubir Banerjee
January-April 2004, 49(1):22-24
Fifteen children aged 3 to 15 (mean 8.92) years with moderate to severe atopic dermatitis (AD) of 6 months to 5 years (mean 2.5 years) duration were treated with 0.1% topical tacrolimus ointment. Tacrolimus ointment was applied on 3 patches of 3 x 3 cm, twice daily for 2 weeks. An equal number of age and sex matched controls were treated with sunflower oil application on eczema lesions. There was significant reduction of severity scores (P < 0.05) after tacrolimus treatment as compared to sunflower oil application in all 15 children. Three children experienced mild and transient burning, erythema and pruritus over the lesions. Topical tacrolimus (0.1%) was found to be effective and safe in the treatment of moderate to severe AD in children.
[ABSTRACT]   Full text not available  [PDF]
  886 127 -
Lichen Planus Pemphigoides
Deepa Mathew, Ramesh M Bhat
January-April 2004, 49(1):32-34
We report a case of lichen planus pemphigoides. The patient had features of lichen planus and bullous pemphigoid. It was proved by histopathology and immunofluorescence test.
[ABSTRACT]   Full text not available  [PDF]
  809 144 -
Non-infectious Granulomatous Dermatits - A Clinico-pathological Approach To Diagnosis
Harsh Mohan, Amanjit Bal
January-April 2004, 49(1):1-8
Full text not available  [PDF]
  604 216 -
Juvenile Xanthogranuloma With Hydrocephalus
Arghyaprasun Ghosh, Kakali Mandal, Asok Samanta, Jayashree Nath Barbhuiya, Sunil Kumar Dey
January-April 2004, 49(1):40-41
Juvenile xanthogranuloma (JXG) is a rare, benign, self-healing tumor of unknown etiology arising from non-Langerhans’ cell histiocytes. We report a case of 2 year old female child with few nodular lesions mainly over scalp, face, trunk and upper limbs. There was no other organ involvement. Histopathology showed presence of vacuolated histiocytes with Touton giant cells. There was concurrent hydrocephalus.
[ABSTRACT]   Full text not available  [PDF]
  753 45 -
Basal Cell Carcinoma : Evaluation Of Clinical And Histologic Variables
Mamata Mahanthesh, Karuna Rameshkumar
January-April 2004, 49(1):25-27
A retrospective review of 32 patients with basal cell carcinoma was performed with aims to characterize the demographic profile and to analyze the clinical and histological parameters influencing the treatment of basal cell carcinoma. The maximum number occurred in the sixth decade with an unusual female preponderance. Hisologically, the classic type predominated while the other types included pigmented, morphoea, metatypical, adenoid, eccrine, firoepihelioma and superficial spreading type. All patients had excision of the tumour with involvement of surgical margin in three of them. None of the three patients belonged to aggressive histological types, such as morphoea or metatypical type. Two year follow-up showed no recurrence. Size of the tumor less than 2 cm, absence of ulceration and a good inflammatory response were probably other reasons for non-recurrence.
[ABSTRACT]   Full text not available  [PDF]
  635 111 -
Angiolymphoid Hyperplasia With Eosinophilia
Shiby Ninan, Kingsly Paul, Ashish Kumar Gupta, P C Austin
January-April 2004, 49(1):37-39
We present three cases of the uncommon condition, angiolymphoid hyperplasia with eosinophilia. Two of them had lesions over pinna and external auditory canal while the third one had subcutaneous lesions with involvement of muscles over cheek and submandibular region.
[ABSTRACT]   Full text not available  [PDF]
  668 69 -
Basal Cell Epithelioma Eroding Into The Eye
V Somasundaram, A M Jayaraaman
January-April 2004, 49(1):35-36
A case of basal cell epitelioma involving and eroding into the right eye with classical clinical and histopathological features has been reported.
[ABSTRACT]   Full text not available  [PDF]
  603 73 -
Patch Testing In Soldiers : An Evaluation
N. S Walia, A. K Jaiswal
January-April 2004, 49(1):14-17
Our study concerns contact sensitization in soldiers, the frequency of which is poorly documented. During a six-year period, 128 patients of age range 17-50 years were patch tested with the Indian standard battery of 30 allergens. We obtained a reaction in 23 (18%) of our patients. Nickel sulfate, fragrance mix, wool alcohol and parthenium induced most of the positive responses. In addition, an irritant reaction was seen in 16 (12.5%) of our patients. Patients of atopic dermatitis and hand/foot dermatoses evoked a high sensitivity response. Adverse effects were seen in 15 patients.
[ABSTRACT]   Full text not available  [PDF]
  588 69 -
Henoch-Schonein Purpura Following Herpes Zoster
Reena Rai, C. R Srinivas
January-April 2004, 49(1):49-49
Full text not available  [PDF]
  499 48 -
Juvenile Elastoma
B Jeevankumar, K Karthikeyan, D. M Thappa, S Jayanthi
January-April 2004, 49(1):46-47
Full text not available  [PDF]
  451 65 -
Syndrome Of Seminal Retention
M S Bhatia, Manish Khandpal, Harsh Sharma
January-April 2004, 49(1):48-48
Full text not available  [PDF]
  435 60 -
Le-Lp Overlap Syndrome
Saumen Chatterjee, Subhra Dhar, Sandipan Dhar
January-April 2004, 49(1):50-50
Full text not available  [PDF]
  428 66 -
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