Indian Journal of Dermatology
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   1990| October-December  | Volume 35 | Issue 4  
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Cutaneous manifestations of neuro fibromatosis type 1 m south India
B Jeevankumar, DM Thappa, R Narasimhan, A. Sahai
October-December 1990, 35(4):218-226
ABSTRACT: Neurofibromatosis type 1 (NF-1) is the most common form of neurofibromatosis. Since the significance of various cutaneous manifestations of NF-1 has not been known in Indian population, hence, the present study was undertaken. A total of patients with NF-1 were identified between August 1998 to June 2000 with a prevalence rate of 20.04 per 10,000 individuals attending our clinic. Male to female ratio was 2.3:1. The age of the patients ranged from 15 to 70 years with a mean age of 29.57 years. Most patients (18 cases) belonged to age group of 21-30 years followed by 11-20 years age group (11 cases). Twenty four cases had onset of disease between 11-20 years of age and ten cases in 21- 30 years age group. Thirty one of 40 cases presented with asymptomatic nodules, three sought medical opinion for cosmetic reasons and another three for hyperpigmented patch. Analysis of cutaneous manifestations showed. 39 of 40 cases (97.5 percent) had neurofibromas. Palmar melanotic macules were noted in 36 (90 percent) cases whereas cafe-au-lait macules were seen in 33 (82.5 percent) cases. Subsequent less common findings were intertriginous freckles in 31 (77.5 percent) cases, plantar melanotic macules in 18 (45 percent) cases and generalised freckles in 4(10 percent) cases. Statistical analysis of cases and controls revealed significant association of NF-1 with neurofibromas, palmar melanotic, cafe-au-lait macules, intertriginous freckles and plantar melanotic macules (p0.001). This study brings into focus some of the cutaneous manifestations noted in South Indian patients especially palmar and plantar melanotic macules, not highlighted in the western literature.
[ABSTRACT]   Full text not available   
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Pityrosporum infection in HIV infected patients
PK Kaviarasan, TJ Jaisankar, DM Thappa, S. Sujatha
October-December 1990, 35(4):215-217
ABSTRACT: An increased colonization of Malassezia furfur organism has been reported in patients with HIV infection. Pityriasis versicolor and pityrosporum folliculitis arise from overgrowth of M. furfur. It is also thought to have a significant role in the pathogenesis of seborrheic dermatitis and is one of the earliest clinical markers of HIV infection. The present study was to note the occurrence and significance of these infections in HIV infected. The occurrence of pityrosporum infection was 13.5 percent (25 cases amongst 185 HIV seropositive patients) in HIV infected cases in our study. Mean Age of the affected patients was 31.7 Years and male to female ratio was 1.5:1. The main mode of acquisition of HIV infection was heterosexual (19 cases). Tinea versicolor was seen in 10 (40 percent) cases, seborrheic dermatitis in 14(56 percent) and pityrosporum folliculitis in 4(16 percent) cases. seborrheic dermatitis was found to be more explosive in onset and involving extensive areas with severe inflammation. Extensive tinea versicolor and seborrheic dermatitis were seen in three cases with pityrosporum infections. Nine of the pityrosporum infections were observed in HIV Group IV, which is equivalent of AIDS. To conclude, seborrheic dermatitis in patients with HIV/AIDS may have some unique features and may be used as a clinical marker of AIDS.
[ABSTRACT]   Full text not available   
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Comparative efficacy of 1 terbinafine hydrochloride and 1 butenafine hydrochloride cream in the treatment of tinea cruris
SK. Rathi
October-December 1990, 35(4):227-228
ABSTRACT: The aim of the study was to evaluate the comparative efficacy of 1 terbinafine hydrochloride and 1 butenafine hydrochloride cream in the treatment of Tinea cruris, was done taking with ten patients in each study group. They were found to be equipotent in one and two week treatment respectively.
[ABSTRACT]   Full text not available   
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Mycological study of tinea corporis & tinea cruris in Ahmedabad
PK Kar, GS Mushtaqali, RC Raval, FE Bilimoria, BH. Shah
October-December 1990, 35(4):115-117
ABSTRACT: Out of 112 cases examined, 57 were suffering from tinea corporis and 55 cases had tinea cruris. 76 were male and 36 were females. The commonest age group affected was between 20 to 30 years. Out of total 112 cases, 59 (52.6 percent) gave positive culture 88 (78.5 percent) cases were positive by smear examination in 10 percent KOH. Trichophyton rubrum was the commonest pathogen isolated in 43 (38.3 percent) cases followed by Candida albicans in 8 (7.1 percent) and Trichophyton mentagrophytes in 4 (3.5 percent) cases.
[ABSTRACT]   Full text not available   
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Cutaners leishmaniasis
PN Arora, KR Ramakrishanan, JR Bhardwaj, KV. Singh
October-December 1990, 35(4):123-127
ABSTRACT: A total of 21 patients with skin lesions were clinically diagnosed as suffering from cutaneous leishmaniasis during the 3 years period. 18 of the patients had leishmania tropica (Oriental sores) and 3 had post-kala-azar dermal leishmaniasis. The patients were all males, 17 being in the 3rd decade of life. The number varied from a solitary lesion to more than 20. Face, feet and hands were the commonest site. Generalised lesions were present in 4 patients. Duration varied from one month to 3 years. Majority of patients suffering from L. tropica had noduloulcerative lesions and those of post-kala-azar dermal leishmaniasis had multiple nodular lesions. Oriental sores occurred in those employed in Rajasthan sector. Biopsy done in all patients revealed LD bodies in 7 cases of oriental sores and 2 cases of post-kala-azar dermal leishmaniasis. Immunoglobulin profiles showed raised IgG and IgM in 6 cases of oriental sores and all the 3 cases of post-kala-azar dermal leishmaniasis. Out of 8 cases of oriental sores, 5 were treated with antibiotics, 6 with antibiotics-steroids combination and remaining 7 with conventional doses of sodium antimony gluconate out of which 2 patients relapsed. The serum immunoglobuline of both the patients with post-kala-azar dermal leishmaniasis remaned high inspite of treatment and clinical response.
[ABSTRACT]   Full text not available   
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Subcutaneous zygomycosis : basidiobolomycosis
G Sethuraman, S Kuruvilla, L. Joseph
October-December 1990, 35(4):242-244
ABSTRACT: Subcutaneous zygomycosis, also known as basidiobolomycosis, is a rare disease caused by the fungus Basidiobolus ranarum. Since its first description in 1954, many cases have been reported. In India, so far only few cases have been described. We report this entity in a 3-year old female child who had firm to hard swelling of the right upper extremity and chest. Histopathology showed short aseptate hyphae surrounded by eosinophilic material within the granulomatous tissue response, in the subcutaneous tissue. She responded dramatically to saturated solution of potassium iodide.
[ABSTRACT]   Full text not available   
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Clinicoepidemiological study of warts
AJ Kanwar, SC Bharija, G. Singh
October-December 1990, 35(4):111-114
ABSTRACT: Clinico-epidemiological features of 320 patients suffering from warts are reported. Males comprised 64.06 percent of patients and maximum number 202 (63.12 percent) were in the age group 11-30 years. The commonest type (59.38 percent) of warts were planter warts; the incidence of other types was verruca vulgaris (32.5 percent), condylomata acuminata (3.44 percent), verruca plana (3.12 percent), verruca filiformis (1.25 percent) and epidermodysplasia verruciformis (0.3 percent). A positive family history of warts was obtained in 34 (10.62 percent) cases. Treatment of various types of warts is also highlighted.
[ABSTRACT]   Full text not available   
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Annular elastolytic giant cell granuloma
S Khandpur, BSN. Reddy
October-December 1990, 35(4):238-241
ABSTRACT: The clinical and histopathological features of annular elastolytic giant cell granuloma in a 42-year-old female patients are described. The condition presented as annular erythematous plaques over sun-exposed skin sparing the face. Histopathology revealed dense granulomatous infiltrate consisting of numerous giant cells and lymphohistiocytes without any palisading arrangement or necrobiosis. The features differentiating it from other similar granulomatous disorders are discussed.
[ABSTRACT]   Full text not available   
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Primary tuberculosis of the glans penis
B Dutta, G Chatterjee, TK. Das
October-December 1990, 35(4):245-247
ABSTRACT: Primary tuberculosis of the glans penis is extremely rare. We report a case in a 47 years old man who presented with an ulcer over glans which mimicked malignancy. The diagnosis of tuberculosis was confirmed by biopsy and response to antituberculous chemotherapy. There was no co-existing tuberculous infection elsewhere. The wife of the patients was under treatment for pulmonary tuberculosis. The possibility of acquiring the disease following sexual contact could not be ruled out. The importance of biopsy in the diagnosis of chronic genital ulcer is emphasised.
[ABSTRACT]   Full text not available   
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Mucocutaneous Fungal Infections Of Significance in HIV Infected individuals in India
DM. Thappa
October-December 1990, 35(4):203-211
ABSTRACT: Mucocutaneous disorders remain one of the most important clinical markers of the stages of HIV infection from time of seroconversion. they function as visual markers in assessing the progression of HIV disease. In development countries, CD4 lymphocyte count, detection of viral specific RNA, and viral culture are being used for the assessment of HIV disease. Lack of these facilities in third world countries like India, Necessitates dependence on clinical markers. HIV infected person present with various cutaneous dermatoses, fungal dematoses being the most common . Many a times, cutaneous and mucosal fungal infections may give a clue to the underlying HIV infection. The increased incidence of candidal, dermatophytic and pityrosporum infections in HIV infected individuals, even in India is well established. Moreover, they are more extensive, often atypical and aggressive, sometimes life threatening. Clinicians should be aware of the various common mucocutaneous disorders in HIV disease especially fungal disorders in their specialties, because they can be used in the diagnosis and assessment of the stage of immunodeficiency at the time of presentation.
[ABSTRACT]   Full text not available   
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Necrobiosis lipoidica diabeticorum
P Kanchan, DP Jayanth, SD Shenoi, A. Sandra
October-December 1990, 35(4):231-233
ABSTRACT: We present a case of necrobiosis lipoidica in a 55 year old Female diabetic patient with multiple, disseminated lesions on both the legs, forearms trunk, buttocks and face
[ABSTRACT]   Full text not available   
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Wells syndrome mimicking erythema elevatum diutinum
R Rai, VK Sharma, I Kaur, B. Kumar
October-December 1990, 35(4):229-230
ABSTRACT: Wells syndrome is a rare inflammatory dermatosis clinically by recurrent itchy erythematous oedematous plaques with features resembling both urticaria and cellulitis and histologically characterised by tissue eosinophilia, oedema and flame figures. Erythema elevatum diutinum (EED) is a chronic localised from of cutaneous vasculitis clinically consisting of symmetrical papules and nodules most often on the back of the hands. We present a case of Wells syndrome mimicking EED clinically.
[ABSTRACT]   Full text not available   
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Prognostic value of immunoglobulin profile in human papilloma virus infection
SP. Chattopadhyay
October-December 1990, 35(4):212-214
ABSTRACT: Present study aimed at defining the prognostic value of immunoglobulin profile in human papilloma virus infection by assessing and correlating the levels of immunoglobulin with type, number, duration and response to therapy in 54 randomly selected cases from age group 8 to 42 year (male 35, female 19). Raised 1gG levels were seen maximally in all spectrum of warts (59.25 percent) followed by 1gM (40.74 percent) and 1gA (25.92 percent). It was also seen that 82 percent of cases with elevated 1gM and 1gA and 1gA were free from lesions with no recurrence at 6 months follow up with any from of treatment (electrodesiccation, 25 percent podophyllin, 50 percent trichloroacetic acid, 5 percent 5-fluorouracil). On the contrary, patients with elevated 1gG level showed poor response (64 percent) and partial response (16 percent) with recurrence of (38 percent) at the end of 6 months. Cure rate was 54 percent) with combined elevation of 1gG, 1gA and 1gM with recurrence rate of 24 percent
[ABSTRACT]   Full text not available   
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Bilateral naevus of ota
QM Ahmad, I Hassan, S. Qayoom
October-December 1990, 35(4):248-249
ABSTRACT: Naevus of Ota is a type of dermal melanocytic naevus characterized by extensive blue patch of dermal melanocytic pigmentation of the sclera and the skin adjacent to the eye. The condition is usually unilateral. Here we report a patient with bilateral naevus of Ota in view of the rarity of this condition.
[ABSTRACT]   Full text not available   
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Acquired cutis laxa
SK Sayal, KS Dhillon, GK. Prasad
October-December 1990, 35(4):255-256
ABSTRACT: A case of acquired cutis laxa is presented for its rarity.
[ABSTRACT]   Full text not available   
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Mal de meleda Type of keratoderma
D Pandhi, BSN. Reddy
October-December 1990, 35(4):252-254
ABSTRACT: A child born of a consanguineous marriage showing characteristic features of Mal de Meleda type of palmoplantar keratoderma is reported for its rarity and clinical interest.
[ABSTRACT]   Full text not available   
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Co-existence of seborrhoeic keratosis and lentigo senilis
AK Gangopadhyay, SK. Panja
October-December 1990, 35(4):129-131
Full text not available   
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Disabling pansclerotic morphea of children
J Chakravarty, A Coondoo, R. Banerjee
October-December 1990, 35(4):234-235
ABSTRACT: A case of disabling pansclerotic morphea in a female child of 9 year with unusual involvement of the digits is reported.
[ABSTRACT]   Full text not available   
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Monilethrix : report of a family
M Bhalla, GP Thami, AJ Kanwar, S. Kaur
October-December 1990, 35(4):250-251
ABSTRACT: Monilethrix is a rare inherited structural defect of the hair shaft resulting in increased fragility of the hair. It is a genetically heterogenous condition. We describe a family with autosomal recessive inheritance with four members affected and a significant correlation of disease with consanguineous marriages in the family.
[ABSTRACT]   Full text not available   
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"Blindness due to leprosy and its socio-economic aspects"
PR Chatterjee, SM Sinha, BK Baidya, DN Chattopadhyay, A Ghosh, A Banerjee, S Chatterjee
October-December 1990, 35(4):118-122
ABSTRACT: A total number of 800 cases of leprosy of both sexes were studied and 87.75 percent cases had some forms of ocular involvement Blindness was noted in 3.7 percent of cases. Of which 2.56 percent had bilateral and 1.13 percent unilateral blindness. The main cause of blindness was occlusio pupliae and complicated cataract. Blindness was mostly seen in agriculturers (35.29 percent) next to them were labourers (17.64 percent), rickshaw pullers (11.64 percent), sweepers (8.82 percent) and beggars (8.82 percent) respectively. The most of them (94.12 percent) were from lower socio-economic groups. So, we emphasize the importance of routine and regular ocular examination of all leprosy cases as soon as the disease is diagnosed in order to save the eyes from serious complications e.g. blindness.
[ABSTRACT]   Full text not available   
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Naevus lipomatosus cutaneous superficialis
C Ramanan, A Ghorpade, MN Das, P Mercy, U. Bose
October-December 1990, 35(4):236-237
ABSTRACT: Naevus lipomatosus cutaneous superficialis (NLCS) in an eighteen year old female is reported. She had asymptomatic nodules and plaques on her lower back since birth. The diagnosis was confirmed by histopathology.
[ABSTRACT]   Full text not available   
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