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Indian Journal of Dermatology
  Publication of IADVL, WB
  Official organ of AADV
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THERAPEUTIC ROUNDS
Treatment of periocular hyperpigmentation due to lead of kohl (surma) by penicillamine: A single group non-randomized clinical trial
Omar Soliman El Safoury, Dina Sabry Abd El Fatah, Magdy Ibrahim
October-December 2009, 54(4):361-363
DOI:10.4103/0019-5154.57614  PMID:20101339
Background: Periocular hyperpigmentation is a condition in which skin of eyelids become darker in color than the normal surrounding skin. Lead and other heavy metals produce increased pigmentation because of deposition of metal particles in the dermis and increased epidermal melanin production. Aims: This study was conducted to evaluate the dual effect of chelation therapy in treating periocular hyperpigmentation and lead toxicity. Methods: The study population consisted of nine females complaining from dark coloration of their eyelids. The nine females were continuously using kohl as eyeliner. Lead levels in conjunctiva and serum before and after D-penicillamine (D-PCN) oral administration were estimated in relation to vertical, horizontal length, and degree of hyperpigmentation score. Results: Highly significant P values (0.000) were obtained as regard to the conjunctival lead levels, serum lead levels, horizontal length, and degree of darkness score before and after D-PCN therapy. A less significant P value (0.040) was recorded as regard to the vertical length. Conclusion: Regardless other causes, this study spots the light on a new concept for periocular hyperpigmentation from lead toxicity in adult females using kohl and suggests D-PCN in a low divided dose (750 mg/day) for its treatment.
  52,764 285 2
CME ARTICLE
Sexually transmitted infections in India: Current status (except human immunodeficiency virus/acquired immunodeficiency syndrome)
Devinder Mohan Thappa, Sowmya Kaimal
April-June 2007, 52(2):78-82
DOI:10.4103/0019-5154.33283  
Sexually transmitted infections (STIs) are more dynamic than other infections prevailing in the community. It is important that such dynamic epidemiological changes in STIs are acknowledged and kept track of in a vast and populous developing country like India, particularly in this HIV era. It is with this aim that the authors have reviewed the relevant literature in STI epidemiology in India during the past 25 years. Admittedly, there has been heterogeneity of data to account for the subcontinental dimension of this country. But a basic pattern in the changing epidemiology is discernible. Like the developed countries, in India too the bacterial STIs like chancroid and gonorrhea are declining, while viral STIs like HPV and herpes genitalis are on an upswing. The overall decline in the prevalence of STIs has to be interpreted with caution, however. This may partially reflect the improved facilities of treatment in the peripheral centres that obviates the need of many patients in attending the STD clinics in the tertiary centres. Also, the improved pharmacotherapy of many of the bacterial STIs may result in partial clearance and non-reporting of many of these infections.
  44,419 1,252 10
BASIC RESEARCH
Characterization of Malassezia Furfur and its control by using plant extracts
R Vijayakumar, C Muthukumar, T Kumar, R Saravanamuthu
April-June 2006, 51(2):145-148
DOI:10.4103/0019-5154.26942  
Malassezia furfur, a lipophilic, dimorphic and yeast-like fungus, occurring in human skin as an opportunistic pathogen, causes diseases such as dandruff, pityriasis versicolar, seborrheic dermatitis, etc. Suitable media for culturing the organism were standardized. A modified medium for the culturing of M. furfur has been proposed. Growth of the fungus was also determined in the presence of different carbon sources under the influence of different temperature, pH and salinity. Plant extracts of 19 species were screened against the growth of the fungus by using disc diffusion method and the results are discussed.
  36,698 1,119 13
REVIEW ARTICLES
Deflazacort versus other glucocorticoids: A comparison
Surajit Nayak, Basanti Acharjya
October-December 2008, 53(4):167-170
DOI:10.4103/0019-5154.44786  PMID:19882026
Steroids form an important component of dermatological therapy and are used since very long time for different conditions in different forms. Though very few molecules are used since very long time, the side effect associated with this group of drugs are almost always there. Recently a new molecule deflazacort has been introduced into Indian market, is a glucocorticoid and a derivative of old molecule prednisolone. Though claimed to be having less side effect, very few studies have been done in Indian prospective. This review will highlight the very basics of this drug and its advantages and disadvantages.
  34,921 1,421 18
ORIGINAL ARTICLE
Comparison of three different regimens of oral azithromycin in the treatment of acne vulgaris
Farahnaz Fatemi Naieni, Hooman Akrami
October-December 2006, 51(4):255-257
DOI:10.4103/0019-5154.30288  
Background: Acne vulgaris is a common skin disease that involves pilosebaceous units. Oral antibiotics are the most widely administered drugs, which are prescribed as systemic therapy for treatment of moderate to severe acne vulgaris. Azithromycin is one of the antibiotics that has been recently used for acne treatment. There are several protocols of oral azithromycin in the treatment of acne. Objective: To compare three various regimens of oral azithromycin in the treatment of acne. Materials and Methods: Sixty-four patients with moderate to severe acne were divided into three groups randomly. First group (21 patients) received azithromycin as follow: five consecutive days, 500 mg on the first day and 250 mg daily for a further four days per month. Second group (22 patients): 500 mg daily for four consecutive days per month and the last group (21 patients): 250 mg daily thrice weekly. After the baseline visit, patients were scheduled to return at four-weekly intervals among 12 weeks. Result: There were no differences between three groups in decreasing of acne grading score. ( P >0.05). Efficacy of minimal dose was equal to maximum dose of azithromycin in treatment of acne. Oral azithromycin in all groups resulted in a significant decrease in acne grading score in each consecutive visit ( P <0.001). Conclusion: Because of expensiveness of azithromycin,, we recommend azithromycin in low dose (1500 mg monthly) which is as effective as a high dose (3000 mg monthly) with lower cost, has more compliance and fewer side-effects.
  34,776 675 1
CME ARTICLE
Mycosis fungoides: Current trends in diagnosis and management
Saumya Panda
January-March 2007, 52(1):5-20
DOI:10.4103/0019-5154.31918  
Mycosis fungoides (MF) is the most common group of cutaneous T-cell lymphomas. It is a rare non-Hodgkin's lymphoma of mature, skin-homing, clonal, malignant T lymphocytes, usually observed in mid to late adulthood, that initially presents in the skin as patches, plaques, tumors, or generalized erythema (erythroderma) and can involve the lymph nodes and peripheral blood. Much progress has been made in recent years in understanding the origin of the malignant T cell in MF and the patho-physiology and immunology of the disease. This recent work has made a great impact on diagnosis, prognostication, and treatment. In this review, we survey the MF literature of the last decade and highlight the major trends.
  28,735 1,280 2
CORRESPONDENCES
Triple combination of hydroquinone, tretinoin and mometasone furoate with glycolic acid peels in melasma
Kiran V Godse
January-March 2009, 54(1):92-93
DOI:10.4103/0019-5154.49005  PMID:20049286
  27,915 634 7
CORRESPONDENCE COLUMN
Diagnosing lip swelling
Omar Al Al Akloby, Iqbal A Bukhari
July-September 2005, 50(3):174-175
  28,246 1 -
REVIEW ARTICLE
Radiofrequency ablation in dermatology
Silonie Sachdeva, Alka Dogra
July-September 2007, 52(3):134-137
DOI:10.4103/0019-5154.35091  
Radiofreqeuency ablation is a versatile dermatosurgical procedure used for surgical management of skin lesions by using various forms of alternating current at an ultra high frequency. The major modalities in radiofrequency are electrosection, electrocoagulation, electrodessication and fulguration. The use of radiofrequency ablation in dermatosurgical practice has gained importance in recent years as it can be used to treat most of the skin lesions with ease in less time with clean surgical field due to adequate hemostasis and with minimal side effects and complications. This article focuses on the major tissue effects and factors influencing radiofrequency ablation and its application for various dermatological conditions.
  24,857 918 7
Topical treatment of melasma
Debabrata Bandyopadhyay
October-December 2009, 54(4):303-309
DOI:10.4103/0019-5154.57602  PMID:20101327
Melasma is a common hypermelanotic disorder affecting the face that is associated with considerable psychological impacts. The management of melasma is challenging and requires a long-term treatment plan. In addition to avoidance of aggravating factors like oral pills and ultraviolet exposure, topical therapy has remained the mainstay of treatment. Multiple options for topical treatment are available, of which hydroquinone (HQ) is the most commonly prescribed agent. Besides HQ, other topical agents for which varying degrees of evidence for clinical efficacy exist include azelaic acid, kojic acid, retinoids, topical steroids, glycolic acid, mequinol, and arbutin. Topical medications modify various stages of melanogenesis, the most common mode of action being inhibition of the enzyme, tyrosinase. Combination therapy is the preferred mode of treatment for the synergism and reduction of untoward effects. The most popular combination consists of HQ, a topical steroid, and retinoic acid. Prolonged HQ usage may lead to untoward effects like depigmentation and exogenous ochronosis. The search for safer alternatives has given rise to the development of many newer agents, several of them from natural sources. Well-designed controlled clinical trials are needed to clarify their role in the routine management of melasma.
  23,022 2,579 20
Phototherapy: An Indian perceptive
Reena Rai, CR Srinivas
October-December 2007, 52(4):169-175
DOI:10.4103/0019-5154.37719  
The importance of sunlight has been recognized since long. Ultraviolet light which comprises a small proportion of sunlight is therapeutically useful. Phototherapy is the use of ultraviolet irradiation with or without exogenous photosensitizer. It can be administered as photochemotherapy, Broadband UVB and narrowband UVB therapy, Excimer laser, UVA1 phototherapy and photodyanamic therapy. In India, photochemotherapy and narrowband UVB therapy are widely used for treatment of various dermatological problems. This article discusses the treatment protocols and the various modalities of treatment by phototherapy.
  23,539 1,324 3
Unraveling the mystery of vernix caseosa
Gurcharan Singh, G Archana
April-June 2008, 53(2):54-60
DOI:10.4103/0019-5154.41645  PMID:19881987
Vernix caseosa is a white, creamy, naturally occurring biofilm covering the skin of the fetus during the last trimester of pregnancy. Vernix coating on the neonatal skin protects the newborn skin and facilitates extra-uterine adaptation of skin in the first postnatal week if not washed away after birth. It consists of water-containing corneocytes embedded in a lipid matrix. The strategic location of the vernix on the fetal skin surface suggests participation in multiple overlapping functions required at birth, such as barrier to water loss, temperature regulation, and innate immunity. Vernix seems to perform various integral roles during transition of the fetus from intra-uterine to extra-uterine life. It has also found various interesting diagnostic and prognostic implications in this arena. Thus, it continues to be an intriguing topic of interest among the medical fraternity to understand its detailed biology and function in the fetus and also to put its naturally endowed characteristics to use in the adult population.
  23,183 530 8
CASE REPORTS
Squamous cell carcinoma of the penis and scrotum in a patient with chronic scrotal and penile lymphedema
Suhas V Abhyankar, Ananta Kulkarni, Madhuri Kulkarni, Naveen Kumar Agarwal
October-December 2010, 55(4):387-389
DOI:10.4103/0019-5154.74563  PMID:21430898
Squamous cell carcinoma arising from tissue affected by chronic lymphedema is rare, though it is recognized that a variety of malignant tumors can arise in chronic congenital or acquired lymphedema. We describe, a case of scrotal and penile squamous cell carcinoma arising in a patient with a history of chronic scrotal and penile lymphedema of filarial origin. We here discuss the management and possible etiology of this unusual case.
  22,878 51 2
SPECIAL ARTICLE
Human Demodex Mite: The Versatile Mite of Dermatological Importance
Parvaiz Anwar Rather, Iffat Hassan
January-February 2014, 59(1):60-66
DOI:10.4103/0019-5154.123498  PMID:24470662
Demodex mite is an obligate human ecto-parasite found in or near the pilo-sebaceous units. Demodex folliculorum and Demodex brevis are two species typically found on humans. Demodex infestation usually remains asymptomatic and may have a pathogenic role only when present in high densities and also because of immune imbalance. All cutaneous diseases caused by Demodex mites are clubbed under the term demodicosis or demodicidosis, which can be an etiological factor of or resemble a variety of dermatoses. Therefore, a high index of clinical suspicion about the etiological role of Demodex in various dermatoses can help in early diagnosis and appropriate, timely, and cost effective management.
  21,954 310 1
CME ARTICLE
Neonatal and infantile erythroderma: 'The red baby'
Rashmi Sarkar
July-September 2006, 51(3):178-181
DOI:10.4103/0019-5154.27979  
Neonatal and infantile erythroderma or "the red baby" is a rare condition. It can be potentially life-threatening and requires urgent attention of the dermatologists. The causes of erythroderma in this age group are different from that in adults and distinctive, but maybe difficult to establish due to poor specificity of clinical and laboratory findings. Careful monitoring and management of the patient may improve the final outcome. In this review, the various causes of "the red baby" is discussed along with its prognosis and management.
  21,201 578 5
CASE REPORTS
Genital vitiligo following use of imiquimod 5% cream
Ruzhi Zhang, Wenyuan Zhu
May-June 2011, 56(3):335-336
DOI:10.4103/0019-5154.82501  PMID:21772604
Imiquimod is a small molecule with adjuvant pro-inflammatory effects that can be topically delivered as a cream for treating external genital and perianal warts. In our report, two Chinese males at the ages of 25 and 22 years were treated with imiquimod 5% cream for recurrent condyloma accuminatum, three times per week for 18 and 12. weeks, respectively. Depigmentation were noted and gradually enlarged in the treated areas after the two patients discontinued imiquimod. Therefore, clinicians should be made aware of the possible pigmentary changes associated with application of this cream.
  21,500 93 1
REVIEW ARTICLES
Aloe vera: A short review
Amar Surjushe, Resham Vasani, DG Saple
October-December 2008, 53(4):163-166
DOI:10.4103/0019-5154.44785  PMID:19882025
Aloe vera is a natural product that is now a day frequently used in the field of cosmetology. Though there are various indications for its use, controlled trials are needed to determine its real efficacy. The aloe vera plant, its properties, mechanism of action and clinical uses are briefly reviewed in this article.
  18,870 1,476 46
CME ARTICLE
Androgenetic alopecia - Current status
Jayakar Thomas
October-December 2005, 50(4):179-190
  19,130 897 -
Cosmetic dermatitis
Alka Dogra, Aman Dua
October-December 2005, 50(4):191-195
  19,216 785 -
Dandruff: The most commercially exploited skin disease
S Ranganathan, T Mukhopadhyay
April-June 2010, 55(2):130-134
DOI:10.4103/0019-5154.62734  PMID:20606879
The article discuss in detail about the prevalence, pathophysiology, clinical manifestations of dandruff including the etio-pathology. The article also discusses in detail about various treatment methods available for dandruff. The status of dandruff being amphibious - a disease/disorder, and relatively less medical intervention is sought after for the treatment, dandruff is the most commercially exploited skin and scalp disorder/disease by personal care industries.
  18,462 1,087 11
CORRESPONDENCE COLUMN
Abuse of topical steroid as cosmetic cream: A social background of steroid dermatitis
Sanjay Rathi
April-June 2006, 51(2):154-155
DOI:10.4103/0019-5154.26949  
  18,904 407 5
INTERDISCIPLINARY PLATFORM
Thyroid and skin
Alka Dogra, Aman Dua, Parminder Singh
April-June 2006, 51(2):96-99
DOI:10.4103/0019-5154.26927  
The association of thyroid disorders with skin manifestations is complex. Both hypothryoidism and hyperthyroidism are known to cause these changes. In order to study this association of skin changes in relation to hypothyroidism, a study was carried out in the outpatients department of Dermatology of Dayanand Medical College and Hospital, Ludhiana, over a period of 3 months from Jan-March 2005. Thirty two patients were enrolled in the study and parameters were noted regarding history, general symptoms, cutaneous signs and associated diseases. We found gain in weight (71.85%) and lethargy (65.62%) to be the most common complaints. On cutaneous examination, dry, coarse texture of the skin (56%), pigmentary disorders (37.5%) and telogen effluvium (40.62%) were the most common findings. Other associated disorders were vitiligo, melasma, pemphigus, alopecia areata, xanthelasma palpebrarum, etc.
  18,254 541 2
CME ARTICLE
Hypertrichosis
RG Valia
July-September 2005, 50(3):119-124
  18,499 3 -
STUDIES
A randomized double blind study of the effect of finasteride on hair growth in male patients of androgenetic alopecia
H RY Prasad, Neena Khanna, RK Pandhi
July-September 2005, 50(3):139-145
Eighty male patients with AGA, not treated in the previous 6 months were enrolled in this randomized, double blind, placebo controlled trial to assess the safety and efficacy of finasteride, 1mg daily, on hair growth. Patients were randomized into 2 groups: Group 1 received 1 mg of finasteride daily and Group 2 received a placebo for a period of 12 months. Efficacy was assessed by hair counts, photographic records, patient's self-assessment questionnaire and clinical assessment. Safety was assessed by history taking and laboratory parameters. A total of 39 patients completed the study. Finasteride was rated superior to placebo with respect to all efficacy measures. At the end of study, finasteride treated patients had a mean increase of 20.564.73 hairs compared to a decrease of 9.565.53 hairs in placebo treated patients. Photographically, 69.56% of finasteride treated patients were rated as improved at 12 months compared to only 6.25% of placebo treated patients. Ten (25%) of finasteride treated patients developed adverse effects (5-decreased libido as well as erectile dysfunction, 4-erectile dysfunction, 1-decreased libido). Finasteride in comparison to placebo was effective in promoting hair growth in male patients of AGA. However, the side effects to the drug were high in this study.
  17,475 2 -
EDITORIAL
Newborn skin care revisited
Sandipan Dhar
January-March 2007, 52(1):1-4
DOI:10.4103/0019-5154.31917  
  16,417 925 3
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