Year : 2020 | Volume
: 65 | Issue : 3 | Page : 173--177
Is NAT2 gene polymorphism associated with vitiligo?
Daya Shankar Lal Srivastava1, Kamal Aggarwal2, Gajendra Singh3
1 Department of BTMM and Biochemistry, PGIMS, Pt. B.D. Sharma University of Health Sciences, Rohtak, Haryana, India
2 Department of Skin and VD, PGIMS, Pt. B.D. Sharma University of Health Sciences, Rohtak, Haryana, India
3 College of Pharmacy, PGIMS, Pt. B.D. Sharma University of Health Sciences, Rohtak, Haryana, India
Background: N-acetyltransferase-2 (NAT2) is a phase II xenobiotic enzyme that plays an important role against oxidative stress-mediated reactive oxygen species protection. Polymorphism in specific genotypes of NAT2 may lead to increase an imbalance in antioxidant systems and may influence the pathogenesis of vitiligo. We conducted this study to see the association between NAT2 gene polymorphism and risk of vitiligo. We looked into whether single-nucleotide polymorphisms (SNP) at positions 857, 481 and 590 of the coding region of the NAT2 gene play as a risk factor for vitiligo among north Indian people. Materials and Methods: In this study, we assessed 100 patients with vitiligo and 160 healthy individuals as controls. Genomic DNA was extracted from human peripheral blood and polymerase chain reaction–restricted fragment length polymorphism was done to identify the single nucleotide polymorphism at positions 857, 481, and 590 of the coding region of the NAT2 gene. Results: In this study, we observed a significant higher risk with slow acetylator genotypes of NAT2 (OR = 2.85; 95% CI = 1.68-4.84, P value < 0.001) for the vitiligo. Furthermore, in the association between NAT2 acetylator genotypes with percentage of body surface area (BSA) of disease, we observed that slow acetylator genotypes of NAT2 has significant higher risk with low grade of disease (1%–10% >11%–30% >30% of BSA). Limitations: A major limitation of this study was the small sample size and warrants further investigation on a large epidemiological study to confirm these findings. Conclusions: Our preliminary data indicate that NAT2 slow acetylator genotype exhibits significant association for the risk of vitiligo, especially in disease predisposition and initiation.
Daya Shankar Lal Srivastava
Department of BTMM and Biochemistry, Pt. B.D. Sharma Post Graduate Institute of Medical Sciences, Rohtak - 124 001, Haryana
|How to cite this article:|
Lal Srivastava DS, Aggarwal K, Singh G. Is NAT2 gene polymorphism associated with vitiligo?.Indian J Dermatol 2020;65:173-177
|How to cite this URL:|
Lal Srivastava DS, Aggarwal K, Singh G. Is NAT2 gene polymorphism associated with vitiligo?. Indian J Dermatol [serial online] 2020 [cited 2020 Jun 4 ];65:173-177
Available from: http://www.e-ijd.org/article.asp?issn=0019-5154;year=2020;volume=65;issue=3;spage=173;epage=177;aulast=Lal;type=0