Indian Journal of Dermatology
SHORT COMMUNICATION
Year
: 2019  |  Volume : 64  |  Issue : 3  |  Page : 213--216

Fixed tapering dosage of acitretin in patients with psoriasis: A short-term analysis of clinical efficacy and its effects on biochemical parameters


Varadraj V Pai, Diksha Phadke, Pankaj Shukla, Krupeksha Naik 
 Department of Dermatology, Venereology and Leprosy, Goa Medical College, Bambolim, Goa, India

Correspondence Address:
Dr. Varadraj V Pai
Department of Dermatology, Goa Medical College, Goa - 403 202
India

Background: Acitretin is a widely used systemic retinoid in the treatment of psoriasis. Dosage of acitretin in not weight adjusted due to certain interindividual variations. Objective: To evaluate the clinical efficacy and effects on biochemical parameters of fixed tapering dosage of acitretin in patients with psoriasis administered over a period of 4 weeks. Materials and Methods: This was an observational study. The study included patients of psoriasis vulgaris in the age group of 18 and 65 years with a psoriasis area severity index (PASI) score of >10 which was not responsive to topical therapy and phototherapy. Patients were given oral acitretin daily at a dose of 25 mg BD for 2 weeks, which was later tapered to 25 mg OD for another 2 weeks. The clinical efficacy and biochemical parameters were assessed. Results: Out of the 18 patients, PASI 75 was achieved in 66% of the patients by the end of the third week. Significant elevations were noted in serum lipids during 4 weeks, which returned to normal limits or near baseline levels at the end of 4 weeks. Conclusion: Fixed tapering dose of acitretin is effective in psoriasis with minimal clinical and biochemical adverse events


How to cite this article:
Pai VV, Phadke D, Shukla P, Naik K. Fixed tapering dosage of acitretin in patients with psoriasis: A short-term analysis of clinical efficacy and its effects on biochemical parameters.Indian J Dermatol 2019;64:213-216


How to cite this URL:
Pai VV, Phadke D, Shukla P, Naik K. Fixed tapering dosage of acitretin in patients with psoriasis: A short-term analysis of clinical efficacy and its effects on biochemical parameters. Indian J Dermatol [serial online] 2019 [cited 2020 Feb 16 ];64:213-216
Available from: http://www.e-ijd.org/article.asp?issn=0019-5154;year=2019;volume=64;issue=3;spage=213;epage=216;aulast=Pai;type=0