Indian Journal of Dermatology
REVIEW ARTICLE
Year
: 2011  |  Volume : 56  |  Issue : 2  |  Page : 137--144

Cutaneous drug hypersensitivity : Immunological and genetic perspective


Kisalay Ghosh1, Gautam Banerjee2, Asok Kumar Ghosal1, Jayoti Nandi3 
1 Department of Dermatology, MGM Medical College and LSK Hospital, Kishanganj, Bihar, India
2 Department of Dermatology, IPGMER, Kolkata, India
3 Sri Aurobindo Seva Kendra, Kolkata, West Bengal, India

Correspondence Address:
Kisalay Ghosh
83 Dumdum Park, Kolkata - 700 055
India

Drug hypersensitivity is an unpredictable, immunologically mediated adverse reaction, clustered in a genetically predisposed individual. The role of «DQ»hapten concept«DQ» in immune sensitization has recently been contested by the «DQ»pharmacological interaction«DQ» hypothesis. After completion of the «DQ»human genome project«DQ» and with the availability of high-resolution genotyping, genetic susceptibility to hypersensitivity for certain drugs has been proved beyond doubt though the trend is ethnicity and phenotype dependent. Application of this newly acquired knowledge may reduce or abolish the morbidity and mortality associated with cutaneous drug hypersensitivity.


How to cite this article:
Ghosh K, Banerjee G, Ghosal AK, Nandi J. Cutaneous drug hypersensitivity : Immunological and genetic perspective.Indian J Dermatol 2011;56:137-144


How to cite this URL:
Ghosh K, Banerjee G, Ghosal AK, Nandi J. Cutaneous drug hypersensitivity : Immunological and genetic perspective. Indian J Dermatol [serial online] 2011 [cited 2020 Apr 6 ];56:137-144
Available from: http://www.e-ijd.org/article.asp?issn=0019-5154;year=2011;volume=56;issue=2;spage=137;epage=144;aulast=Ghosh;type=0