Indian Journal of Dermatology
THERAPEUTIC ROUND
Year
: 2009  |  Volume : 54  |  Issue : 4  |  Page : 361--363

Treatment of periocular hyperpigmentation due to lead of kohl (surma) by penicillamine: A single group non-randomized clinical trial


Omar Soliman El Safoury1, Dina Sabry Abd El Fatah2, Magdy Ibrahim3 
1 Department of Dermatology, Research Biostatistics Unit, Management Team, EBM Unit, MEDC, Cairo University, Egypt
2 Department of Biochemistry, Research Biostatistics Unit, Management Team, EBM Unit, MEDC, Cairo University, Egypt
3 Department of Obstetrics & Gynecology, Research Biostatistics Unit, Management Team, EBM Unit, MEDC, Cairo University, Egypt

Correspondence Address:
Omar Soliman El Safoury
1-ibn Kotaiba Street 7th Part Nnasr, Cairo
Egypt

Background: Periocular hyperpigmentation is a condition in which skin of eyelids become darker in color than the normal surrounding skin. Lead and other heavy metals produce increased pigmentation because of deposition of metal particles in the dermis and increased epidermal melanin production. Aims: This study was conducted to evaluate the dual effect of chelation therapy in treating periocular hyperpigmentation and lead toxicity. Methods: The study population consisted of nine females complaining from dark coloration of their eyelids. The nine females were continuously using kohl as eyeliner. Lead levels in conjunctiva and serum before and after D-penicillamine (D-PCN) oral administration were estimated in relation to vertical, horizontal length, and degree of hyperpigmentation score. Results: Highly significant P values (0.000) were obtained as regard to the conjunctival lead levels, serum lead levels, horizontal length, and degree of darkness score before and after D-PCN therapy. A less significant P value (0.040) was recorded as regard to the vertical length. Conclusion: Regardless other causes, this study spots the light on a new concept for periocular hyperpigmentation from lead toxicity in adult females using kohl and suggests D-PCN in a low divided dose (750 mg/day) for its treatment.


How to cite this article:
El Safoury OS, Abd El Fatah DS, Ibrahim M. Treatment of periocular hyperpigmentation due to lead of kohl (surma) by penicillamine: A single group non-randomized clinical trial.Indian J Dermatol 2009;54:361-363


How to cite this URL:
El Safoury OS, Abd El Fatah DS, Ibrahim M. Treatment of periocular hyperpigmentation due to lead of kohl (surma) by penicillamine: A single group non-randomized clinical trial. Indian J Dermatol [serial online] 2009 [cited 2020 Aug 4 ];54:361-363
Available from: http://www.e-ijd.org/article.asp?issn=0019-5154;year=2009;volume=54;issue=4;spage=361;epage=363;aulast=El;type=0