Indian Journal of Dermatology
BASIC RESEARCH
Year
: 2009  |  Volume : 54  |  Issue : 4  |  Page : 319--322

Quantitation of mast cells and collagen fibers in skin tags


Omar Soliman El Safoury1, Marwa M Fawzy1, Zeinab M El Maadawa2, Dalia H Mohamed1 
1 Department of Dermatology, Cairo University, Egypt
2 Department of Histology, Cairo University, Egypt

Correspondence Address:
Omar Soliman El Safoury
Department of Dermatology, Faculty of Medicine, Cairo University
Egypt

Background: Skin tags are common benign skin tumors usually occurring on the neck and major flexors of elder people. Aims: The aim of this study is to perform quantitation of mast cells and collagen fibers in skin tags and normal skin in diabetics and nondiabetics, to find a possible correlation between mast cells and collagen fibers in the pathogenesis of skin tags. Methods: Thirty participants with skin tags were divided into two groups (15 diabetic and 15 nondiabetic). Three biopsies were obtained from one anatomical site: A large skin tag, a small skin tag, and adjacent normal skin. Mast cells stained with Bismarck brown were counted manually in ten different fields of each section with magnification Χ1000 and the average count was correlated with the percentage of mean collagen area in five fields done by the image analyzer. Results: A statistically significant correlation between mast cell count and percentage of collagen mean area was detected in both studied groups (except in large skin tags of the nondiabetic group). Conclusion: The positive correlation between mast cell count and percentage of collagen mean area suggests the critical role of mast cells in the etiogenesis of skin tags through its interaction with fibroblasts.


How to cite this article:
El Safoury OS, Fawzy MM, El Maadawa ZM, Mohamed DH. Quantitation of mast cells and collagen fibers in skin tags.Indian J Dermatol 2009;54:319-322


How to cite this URL:
El Safoury OS, Fawzy MM, El Maadawa ZM, Mohamed DH. Quantitation of mast cells and collagen fibers in skin tags. Indian J Dermatol [serial online] 2009 [cited 2019 Dec 12 ];54:319-322
Available from: http://www.e-ijd.org/article.asp?issn=0019-5154;year=2009;volume=54;issue=4;spage=319;epage=322;aulast=El;type=0