Indian Journal of Dermatology
CORRESPONDENCE
Year
: 2009  |  Volume : 54  |  Issue : 2  |  Page : 192-

A systematic metanalysis on diagnostic value of DsG3 elisa for pemphigus vulgaris


Viroj Wiwanitkit 
 Wiwanitkit House, Bangkhae, Bangkok, 10160, Thailand

Correspondence Address:
Viroj Wiwanitkit
Wiwanitkit House, Bangkhae, Bangkok, 10160
Thailand




How to cite this article:
Wiwanitkit V. A systematic metanalysis on diagnostic value of DsG3 elisa for pemphigus vulgaris.Indian J Dermatol 2009;54:192-192


How to cite this URL:
Wiwanitkit V. A systematic metanalysis on diagnostic value of DsG3 elisa for pemphigus vulgaris. Indian J Dermatol [serial online] 2009 [cited 2020 Jul 15 ];54:192-192
Available from: http://www.e-ijd.org/text.asp?2009/54/2/192/53181


Full Text

Sir,

Pemphigus vulgaris is an important dermatological immune disorder. It presents with blistering skin lesions. Recently, enzyme-linked immunosorbent assay (ELISA) using desmoglein (Dsg) 3 has become the new diagnostic tool for this skin disease. The diagnostic value of Dsg3 ELISA test is varied in different settings. In addition, most reports on the diagnostic value of Dsg3 ELISA contained only a few subjects. Therefore, a systematic metanalysis on this topic is required. In this paper, the author summarizes the diagnostic value of Dsg3 ELISA for pemphigus vulgaris. There are four quoted papers [1],[2],[3],[4] on this topic. There are 232 cases and 446 controls [Table 1]. According to this study, the overall sensitivity and specificity are equal to 90.5 and 98.7%, respectively. This can imply the good diagnostic property of Dsg3 ELISA for pemphigus vulgaris.

References

1Huang CH, Chen CC, Wang CJ, Chang YT, Liu HN. Using desmoglein 1 and 3 enzyme-linked immunosorbent assay as an adjunct diagnostic tool for pemphigus. J Chin Med Assoc 2007;70:65-70.
2Harman KE, Gratian MJ, Seed PT, Bhogal BS, Challacombe SJ, Black MM. Diagnosis of pemphigus by ELISA: A critical evaluation of two ELISAs for the detection of antibodies to the major pemphigus antigens, desmoglein 1 and 3. Clin Exp Dermatol 2000;25:236-40.
3Amagai M, Tsunoda K, Zillikens D, Nagai T, Nishikawa T. The clinical phenotype of pemphigus is defined by the anti-desmoglein autoantibody profile. J Am Acad Dermatol 1999;40:167-70.
4Ishii K, Amagai M, Ohata Y, Shimizu H, Hashimoto T, Ohya K, et al . Development of pemphigus vulgaris in a patient with pemphigus foliaceus: Antidesmoglein antibody profile shift confirmed by enzyme-linked immunosorbent assay. J Am Acad Dermatol 2000;42:859-61.