Year : 2008 | Volume
: 53 | Issue : 2 | Page : 49--53
Latest laser and light-based advances for ethnic skin rejuvenation
Mohamed Lotfy Elsaie, Heather Woolery Lloyd
Department of Dermatology and Cutaneous Surgery, University of Miami Cosmetic Center, Fl, USA
Mohamed Lotfy Elsaie
Department of Dermatology and Cutaneous Surgery, University of Miami Cosmetic Center, Fl
Background: Advances in nonablative skin rejuvenation technologies have sparked a renewed interest in the cosmetic treatment of aging skin. More options exist now than ever before to reverse cutaneous changes caused by long-term exposure to sunlight. Although Caucasian skin is more prone to ultraviolet light injury, ethnic skin (typically classified as types IV to VI) also exhibits characteristic photoaging changes. Widespread belief that inevitable or irreversible textural changes or dyspigmentation occurs following laser- or light-based treatments, has been challenged in recent years by new classes of devices capable of protecting the epidermis from injury during treatment. Objective: The purpose of this article is to review recent clinical advances in the treatment of photoaging changes in ethnic skin. This article provides a basis for the classification of current advances in nonablative management of ethnic skin.
|How to cite this article:|
Elsaie ML, Lloyd HW. Latest laser and light-based advances for ethnic skin rejuvenation.Indian J Dermatol 2008;53:49-53
|How to cite this URL:|
Elsaie ML, Lloyd HW. Latest laser and light-based advances for ethnic skin rejuvenation. Indian J Dermatol [serial online] 2008 [cited 2019 Sep 23 ];53:49-53
Available from: http://www.e-ijd.org/text.asp?2008/53/2/49/41643
Advances in nonablative skin rejuvenation technologies have sparked a renewed interest in the cosmetic treatment of aging skin. More options exist now than ever before to reverse cutaneous changes caused by long-term exposure to sunlight. Although Caucasian skin is more prone to ultraviolet light injury, ethnic skin (typically classified as types IV to VI) also exhibits characteristic photoaging changes. Widespread belief that inevitable or irreversible textural changes or dyspigmentation occurs following laser or light-based treatments, has been challenged in recent years by new classes of devices capable of protecting the epidermis from injury during treatment. Ethnic skin represents the majority of the world's population and yet few research studies have targeted the safety and efficacy of cosmetic skin procedures in ethnic skin. This article highlights newer advances in nonablative ethnic skin rejuvenation and evaluates their safety and efficacy.
Defining Ethnic Skin
In addition to grouping people of ethnic descent into classic Fitzpatrick categories of IV to VI to describe their propensity for sun reactivity, it is useful to describe how ethnic features and groups relate to one another. People of ethnic skin comprise the majority of the world's population. These include Asians, who can be subdivided into East Asians (Chinese, Japanese, Koreans), Southeast Asians (Indonesians, Malaysians, Singaporeans, Thais, Cambodians, Vietnamese), and South Asians (Bangladeshis, Indians, Pakistanis, Sri Lankans). Those from East Asia tend to have lighter skin color, although Koreans are generally more brown-skinned than the Chinese or Japanese. Southeast Asians have brown skin color while East Asians and Southeast Asians have a Mongoloid ethnic background. South Asians are of Caucasian ethnic background but have brown to dark brown skin.
Photorejuvenation is defined as the use of visible or infrared light energy sources to reverse the process of sun-induced or environmental damage to the skin.  Visible disruption to the overlying epidermis should not occur while trying to accomplish this in a nonablative manner. The primary objective of nonablative rejuvenation is to improve aesthetic concerns characteristic of photoaged skin, including the appearance of dyspigmentation, static fine wrinkles, coarse texture, prominent pores, and telangiectasias. In contrast, chronological skin aging results in thin skin with reduced elasticity that retains normal skin pigmentation and texture.  A secondary objective includes the recontouring of mild surface irregularities via subsequent dermal collagen remodeling.
In general, all races are susceptible to photoaging.  However, it is clear that photoaging is delayed and less severe in patients with Fitzpatrick's skin phototypes IV to VI. This is due to the photoprotective role of melanin. , Published studies on photoaging in black skin have been limited to African Americans. Photoaging is more prominent in lighter-complexioned African American individuals. In addition, photoaging may not be apparent until the fifth or sixth decade of life. Clinically, the features of photoaging in African Americans can include fine wrinkling, mottled pigmentation, and dermatosis papulosa nigra. African Americans also tend to manifest signs of skin laxity with aging. This is most evident in the nasolabial folds and jaws.  Most studies on the treatment of photorejuvenation in ethnic skin utilize nonablative technologies that will be discussed in this paper.
Fractional photothermolysis (Fraxel SR, Reliant Lasers, Palo Alto, CA, USA) is a novel nonablative erbium:glass (1500 nm) laser treatment for facial rejuvenation.  It is also used for the treatment of melasma and acneiform scarring.  Fractional photothermolysis is performed with a midinfrared laser, which creates microscopic columns of thermal injury. These zones of thermal injury, termed microthermal zones (MTZs), have a diameter that is energy-dependent and ranges from 100 to 160 μm. The depth of penetration ranges from 300 to 700 μm at the energies commonly used for facial rejuvenation (8-12 mJ/MTZ). Relative epidermal and follicular structure sparing are responsible for rapid recovery without prolonged downtime. Melanin is not at risk of selective, targeted destruction; therefore, fractional resurfacing has been used successfully in patients with skin of color. Kono et al .  have described the use of the Fraxel in 35 type IV and V Asian patients and concluded that increased density was more likely to produce swelling, redness, and hyperpigmentation when compared to increased energy. In this study, the authors concluded that patient satisfaction is significantly higher when their skin is treated with high fluences than when treated with high densities. They concluded that fractional photorejuvenation can be safe and effective in darker ethnic skin types. 
Prior studies using fractional photothermolysis have demonstrated its effectiveness in the treatment of photodamaged skin; however, only preliminary results have been reported regarding its use for scars. Given the rapid healing associated with this procedure and its known effect on collagen remodeling, this study was designed to prospectively evaluate the use of fractional photothermolysis in the treatment of atrophic scars. Fifty-three patients (skin phototypes I-V) with mild-to-moderate atrophic facial acne scars received monthly treatment with a 1550 nm erbium-doped fiber laser (Fraxel, Reliant Technologies Inc., San Diego, CA). Clinical response to the treatment was determined by two independent assessors at each treatment visit and six months after the final treatment session, by using a quartile grading scale. Side effects and patient satisfaction were monitored at each follow-up visit. Ninety-one per cent of the patients had at least 25-50% improvement after a single treatment, whereas 87% of the patients receiving three treatments demonstrated at least 51-75% improvement in the appearance of their scars. Moreover, age, sex, and skin phototype also did not significantly affect the observed clinical responses. Hence, it was concluded that fraxel procedures were effective in acne scar treatment for skin of color. 
532 nm Laser
Although not a prominent feature of ethnic skin, treatment of the pigmented and telangiectatic component of photoaging has been reported in ethnic skin. , Rashid and colleagues reported the use of a quasicontinuous wave 532 nm laser in the treatment of lentigines in type IV skin patients.  They showed 50% improvement in lesion clearance, with a 10% incidence of hyperpigmentation and 25% incidence of hypopigmentation after multiple treatments. These side effects abated after two to six months. Lee reported 150 patients with skin types I to V who were treated in multiple sessions with 532 nm (4 mm spot, 6-15 J/cm 2 , 30-50 millisecond pulse duration), 1064 nm (10 mm spot, 24-30 J/cm 2 , 30-65 millisecond pulse duration), or a combination of both.  Sapphire-tipped contact cooling was utilized. Improvement in erythema, texture, pigmentation, and rhytids was reported in both study arms but was highest in the combination group. An incidence of 5% postinflammatory hyperpigmentation was reported in patients with types III and IV skin treated with the 532 nm laser alone, which resolved after 4-6 weeks.  The use of conservative settings to achieve the desired results is prudent. Following these guidelines, the clinician is most likely to achieve a favorable result with the least unwanted side effects. Test spots are necessary to assess the initial patient response and decrease the risk of hypopigmentation, which is often very difficult to treat.
1064 nm Laser
Long-pulsed and Q-switched 1064 nm lasers target melanin as well as hemoglobin and water. Although safer for darker skin, there is a diffuse heating of dermal tissue owing to the deep, penetrating nature of 1064 nm with a typical dispersion depth of 5-10 mm.  One study has shown evidence of improvement with a Q-switched 1064 nm laser for nonablative treatment in type IV skin.  Sun-damaged 4 cm × 4 cm areas of infraauricular skin were exposed to a 1064 nm Q-switched Nd:YAG laser at a fluence of 7 J/cm 2 and a 3 mm spot size. Two laser passes with a 10-20% overlap, were used on all subjects in an attempt to promote petechiae as the visible end point. Petrolatum dressings were applied for a week after treatment. Three millimeter punch biopsy specimens were taken from each subject before treatment. Photographs were taken of the biopsy sites. Three months after the last treatment, another biopsy specimen was taken from a different previously treated area. Histological specimens were evaluated blindly by a board-certified dermatopathologist. Four out of six skin biopsy specimens obtained three months after the last laser treatment, showed mild fibrosis with histological improvement in pretreatment solar elastosis. There was a mildly thickened, upper papillary collagen zone, with an improvement in the organization of collagen fibrils. The remaining two specimens showed no changes. Clinically, none of the treated, nonbiopsied areas showed any evidence of pigmentary changes or scarring. 
Another study utilized the 1064nm Nd:YAG (Laser genesis) for the rejuvenation of facial skin of types I-V. Patients' and masked physician assessment demonstrated overall improvement. Specific improvement was also demonstrated in coarse wrinkles and skin laxity. No adverse events were noted in this study.  Studies have all confirmed the effectiveness and low risk of complication associated with Nd:YAG for rejuvenation in skin of color.
Intense Pulsed Light
Another device for photorejuvenation of ethnic skin is Intense Pulsed Light (IPL). IPL is produced by a noncoherent flashlamp-pumped light source that is capable of emitting light from 500 to 1200 nm.  The use of cutoff filters allows the elimination of some of the shorter wavelengths of the visible light spectrum to limit melanin absorption. Different pulse widths can be chosen so that appropriate parameters match the thermal relaxation times of the targets.  Cooling of the epidermis is achieved with contact cooling in the device head or with external cooling devices.
Negishi and colleagues were among the first to investigate the use of IPL in types IV and V Japanese patients using pulsed light devices. They applied a thin layer of ice-cold gel and they utilized a 550 nm cutoff filter. Settings were 28 to 32 J/cm 2 and 2.5-4.0 and 4.0-5.0 millisecond pulse durations. Excellent results were reported in 73 out of 97 patients. , No evidence of dyspigmentation was reported in either series. Negishi and colleagues have also employed UV photography to identify and treat subclinical epidermal hyperpigmentation with IPL in skin of color.  Although IPL has been utilized with success in skin of color, treatment of such patients should utilize conservative settings to achieve a favorable result with the least unwanted side effects.
Light-emitting diode (LED)
Apart from the light- and laser-based devices described above, three newly described nonablative technologies have been used for treatment in ethnic skin types. Light Emitting Diodes (LEDs) represent the latest advancement in visible spectrum, monochromatic light therapy for photoaged skin. Typically, LEDs in devices are arrayed in panels, and each emits visible light in a ±10-20 nm band around the dominant emitted wavelength. Energy output is less than 25 W, representing a fluence of about 0.1 J/cm 2 . The Gentlewaves LED device (Light Biosciences, Virginia Beach, VA, USA) recently received approval from the US Food and Drug Administration for the treatment of periorbital wrinkling.  In brief, this device is thought to act by targeted stimulation of fibroblastic mitochondrial metabolic activity, concomitant upregulation of procollagen, and downregulation of matrix metalloproteinase I. ,
Radiofrequency (RF) is an electromagnetic radiation in the frequency range of 3 kHz to 300 GHz. The primary effects of RF energy on living tissue are considered to be thermal. The main goal of these new frequency-based devices is to heat specific layers of the skin. Directed use of RF can induce dermal heating and cause collagen degeneration. Wound healing mechanisms promote the remodeling of collagen and wound contraction, which ultimately enhances the appearance of mild to moderate skin laxity. Preliminary studies with one device (Thermacool, Thermage Inc, Hayward, CA, USA) have reported efficacy in the treatment of laxity involving the periorbital area and jowls.  As RF energy is not dependent on specific chromophore interaction, epidermal melanin is not at risk of destruction and treatment of all skin types is possible.
Kushikata et al.  reported the use of RF in a series of 85 Asian patients of dark skin types and concluded that RF treatment was very satisfactory for skin tightening in Asian facial skin. RF appears to be a promising means of photorejuvenation in ethnic skin.
Improvement of facial and cervical skin laxity has been difficult to achieve without surgical procedures. A device called the Titan (Cutera, Inc., Brisbane, California) uses infrared (IR) light to volumetrically heat the dermis. It is designed to thermally induce collagen contraction with subsequent collagen remodeling and neocollagen synthesis. The epidermis is protected via pre-, parallel, and posttreatment cooling. No anesthesia is necessary as there is minimal to no discomfort during the procedure. Improvements in skin laxity and facial and neck contours have been achieved with this device, although results can vary. This variation may be caused by patient variability and differences in technique. 
Few studies have addressed the efficacy and safety of infrared use in darker skin, however Chua et al. investigated the use of IR on 21 patients of Fitzpatrick skin types IV and V. Eighty-six per cent of the patients had improvement as measured by the physician's assessment at their six months' follow-up visit. Hence, Chau et al. concluded that direct application of infrared light with epidermal cooling is effective in achieving gradual, mild-to-moderate clinical improvement in the treatment of facial and neck skin laxity. The procedure is associated with minimal downtime and is safe for use in darker skin types IV and V. 
Plasma skin regeneration (PSR) technology
Plasma is the fourth state of matter acquired by ionizing a gas. One example of this is the light we see with lightning. The electricity (energy) discharged from the clouds to the earth heats up the air (gas) and converts it into plasma.  A basic understanding of skin structure is required to understand how PSR works. Briefly, skin consists of three layers: the epidermis (uppermost layer), dermis (middle layer) and subcutis (lower fat layer). The epidermis contains pigment-producing cells called melanocytes, which are responsible for skin coloring. The dermis is made up of collagen and elastin fibres that provide skin with strength, toughness, elasticity and pliability. The appearance and characteristics of skin change as the body ages. The epidermis becomes thinner so that blemishes become more visible, and collagen in the dermis is gradually lost, which contributes to the formation of facial lines, sagging skin and wrinkles. 
To date, there are five anti-aging treatment regimens - PSR 1, PSR 2, PSR 3, PSR 2/3 combination and a fifth newly FDA approved one. A particular regimen is chosen according to the severity of the problem being treated and the recovery time available. The fifth treatment is a new FDA-approved, anti-aging procedure for treating nonfacial areas of the body. All protocols could be used for lines; however, higher energy treatments are needed for skin tightening. Studies have shown that the thermal energy at 1.0 and 2.0 J was limited to the epidermis and dermoepidermal junction. At 3.0 and 4.0 J, the thermal injury reached the papillary dermis. PSR 1 protocol uses a low-energy treatment spaced three weeks apart. PSR 2 uses a single high pass 3.0-4.0 J energy treatment with a recovery time of 5-7 days. PSR 3 uses two high-energy passes (3.0-4.0 J) with a recovery period of 6-10 days. A fourth protocol uses a combination of PSR 2 and PSR 3 and the fifth one uses very low energy (0.5 J) in a series of three treatments at three-week intervals.  Few studies have been carried out on subjects so far; however, Kilmer,  Poter,  Benstein  and Bogle  have all demonstrated the low risk and efficacy of using such technology in all skin types.
In conclusion, laser procedures in darker skinned patients are challenging but can be successfully achieved if certain treatment guidelines are followed. Discussion of risks and patients' expectations are essential in treating the darker-skinned patient population. Pre- and postlaser cooling can be helpful to minimize side effects and improve patients' comfort. This is especially true with laser hair removal. Photorejuvenation can be successfully achieved with low risk when appropriate settings are used. Fractional technology has increased treatment options for rhytides and atrophic scars. Although there are few studies on LED treatments in skin of color, this type of treatment can be used either as a primary or adjunctive treatment modality with apparently low risk. The 532 nm laser has proved to be risky in skin of color and conservative guidelines should be followed when using it. On the other hand, the 1064 nm laser may offer greater safety when treating ethnic skin albeit still risky in type VI skin. The IPL is a safe option for treating skin of color although it is advisable to limit its use for skin types V and VI. Finally, radiofrequency and newer tightening technologies are safe and highly reliable to use for ethnic skin. However, it is prudent to use conservative settings to achieve the desired results when treating darker skinned patients. The clinician is most likely to achieve a favorable result with the least unwanted side effects if these guidelines are followed.
|1||Weiss RA, McDaniel DH, Geronemus RG. Review of nonablative photorejuvenation: Reversal of the aging effects of the sun and environmental damage using laser and light sources. Semin Cutan Med Surg 2003;22:93-106.|
|2||Kim KH, Geronemus RG. Nonablative laser and light therapies for skin rejuvenation. Arch Facial Plast Surg 2004;26:186-95.|
|3||Griffiths CE, Goldfarb MT, Finkel LJ, Roulia V, Bonawitz M, Hamilton TA, et al. Topical tretinoin (retinoic acid) treatment of hyperpigmented lesions associated with photoaging in Chinese and Japanese patients: a vehicle-controlled trial. J Am Acad Dermatol 1994;30:76-84.|
|4||Kligman AM. Solar elastosis in relation to pigmentation. In : Fitzpatrick TB, Pathak MA, editors. Sunlight and man. Toyko: University of Toyko Press; 1974. p. 157-63.|
|5||Pathak MA. The role of natural photoprotective agents in human skin. In : Fitzpatrick TB, Pathak MA, editors. Sunlight and man. Tokyo: University of Tokyo Press; 1974.|
|6||Matory WE. Skin care. In : Matory WE, editor. Ethinic considerations in facial aesthetic surgery. Philadelphia: Lippincott; 1998. p. 100.|
|7||Manstein D, Herron GS, Sink RK, Tanner H, Anderson RR. Fractional photothermolysis: A new concept for cutaneous remodeling using microscopic patterns of thermal injury. Lasers Surg Med 2004;34:426-38.|
|8||Fisher GH, Geronemus RG Short-term side effects of fractional photothermolysis. Dermatol Surg 2005;31:1245-9.|
|9||Fitzpatrick R, Geronemus R, Goldberg D, Kaminer M, Kilmer S, Ruiz-Esparza J. Multicenter study of noninvasive radiofrequency for periorbital tissue tightening. Lasers Surg Med 2003;33:232-42.|
|10||Kono T, Chan HH, Groff WF, Manstein D, Sakurai H, Takeuchi M, et al. Prospective direct comparison study of fractional resurfacing using different fluences and densities for skin rejuvenation in Asians. Lasers Surg Med 2007;39:311-4.|
|11||Alster TS, Tanzi EL, Lazarus M. The use of fractional laser photothermolysis for the treatment of atrophic scars. Dermatol Surg 2007;33:295-9.|
|12||Lee MW Combination 532-nm and 1064-nm lasers for noninvasive skin rejuvenation and toning. Arch Dermatol 2003;139:1265-76.|
|13||Rashid T, Hussain I, Haider M, Haroon TS. Laser therapy of freckles and lentigines with quasi-continuous, frequency-doubled, Nd:YAG (532 nm) laser in Fitzpatrick type IV: A 24-month follow-up. J Cosmet Laser Ther 2002;4:81-5.|
|14||Dyan SH, Vartanian AJ, Menaker G, Mobley SR, Dayan AN, Nonablative laser resurfacing using the long-pulse (1064-nm) Nd:YAG laser. Arch Fac Plast Surg 2003;5:310-5.|
|15||Goldberg DJ, Silapunt S. Histologic evaluation of a Q-switched Nd:YAG laser in the nonablative treatment of wrinkles. Dermatol Surg 2001;27:744-6.|
|16||Chan HH. Photoaging in Asian. In : Rigel DS, Weiss RA, Lim HW, et al , editors. Photoaging. New York: Marcel Dekker; 2004. p. 343-64.|
|17||Negishi K, Tezuka Y, Kushikata N, Wakamatsu S. Photorejuvenation for Asian by intense pulsed light. Dermatol Surg 2001;27:627-31.|
|18||Negishi K, Wakamtsu D, Kushikata N, Tezuka Y, Kotani Y, Shiba K. Full face photorejuvenation of damaged skin by intense pulsed light with integrated contact cooling: Initial experiences in Asian patients. Lasers Surg Med 2002;30:298-305.|
|19||Negishi K, Kushikata N, Tezuka Y, Takeuchi K, Miyamoto E, Wakamatsu S. Study of the incidence and nature of "very subtle epidermal melasma" in relation to intense pulsed light treatment. Dermatol Surg 2004;30:881-6.|
|20||Gentlewave approval FDA Gentlewave FDA approval. 2005. Cosmetic surgery-news. Available from: http://www.cosmeticsurgery-news.com/article2357.html.|
|21||Weiss RA, Weiss MA, Geronemus RG, McDaniel DH. A novel non-thermal non-ablative full panel led photomodulation device for reversal of photoaging: Digital microscopic and clinical results in various types. J Drugs Dermatol 2004;03:605-10.|
|22||Weiss RA, McDaniel DH, Geronemus RG, Weiss MA. Clinical trial of a novel non-thermal LED array for reversal of photoaging: Clinical, histologic, and surface profilometric results. Lasers Surg Med 2005;36:85-91.|
|23||Hsu TS, Kaminer MS. The use of nonablative radiofrequency technology to tighten the lower face and neck. Semin Cutan Med Surg 2003;22:115-23.|
|24||Kushikata N, Negishi K, Tezuka Y, Takeuchi K, Wakamatsu S. Non-ablative skin tightening with radiofrequency in Asian skin. Lasers Surg Med 2005;36:92-7.|
|25||Bunin LS, Carniol BJ. Cervical facial skin tightening with an infrared device. Fac Plast Surg Clin North Am 2007;15:179-84.|
|26||Chua SH, Ang P, Khoo LS, Goh CL. Nonablative infrared skin tightening in Type IV to V Asian skin: A prospective clinical study. Dermatol Surg 2007;33:146-51.|
|27||Penny K, Sibbons P, Andrews P, Southgate A. A histopathologic assessment of the effects of hydration on the absorption of plasma skin regeneration energy (PSR) in an animal model. Lasers Surg Med 2005;36:23.|
|28||Bogle MA, Plasma skin regeneration technology. Skin Ther Lett 2006;11:7-9.|
|29||Tremblay JF, Moy R. Treatment of post-auricular skin using a novel plasma resurfacing system: An in vivo clinical and histologic study. Lasers Surg Med 2004;34:25.|
|30||Kilmer S, Fitzpatrick R, Bernstein E, Brown D. Long term follow-up on the use of plasma skin regeneration (PSR) in full facial rejuvenation procedures. Lasers Surg Med 2005;36:22.|
|31||Potter M, Harrison R, Ramsden A, Andrews P, Gault D. Facial acne and fine lines: Transforming patient outcomes with plasma skin resurfacing. Lasers Surg Med 2005;36:23.|
|32||Bernstein EF. Very low energy plasma skin resurfacing treatments improve photodamage. Lasers Surg Med 2007;39:17.|
|33||Bogle MA, Arndt KA, Dover JS. Evaluation of plasma skin resurfacing technology in low fluence full-facial rejuvenation. Arch Dermatol 2007;143:168-74.|