Indian Journal of Dermatology
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CASE REPORT
Year : 2020  |  Volume : 65  |  Issue : 3  |  Page : 214-216

Nivolumab-induced bullous pemphigoid managed without drug withdrawal


Department of Dermatology, Germans Trias I Pujol University Hospital, Universitat Autònoma De Barcelona, Badalona, Spain

Correspondence Address:
Mónica Munera-Campos
Department of Dermatology, Germans Trias I Pujol University Hospital, Universitat Autonoma De Barcelona, Carretera De Canyet, S/N, 08916 Badalona, Barcelona
Spain
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijd.IJD_321_18

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The widespread use of anti-programmed cell death receptor-1 (PD-1) agents has shed light to unusual immune-related adverse effects, especially affecting the skin. We report a case of bullous pemphigoid secondary to nivolumab therapy for metastatic renal carcinoma with a previously unreported complete response to clobetasol ointment alone. The autoimmune blistering disease was successfully treated without oral corticosteroids, and the anti-PD-1 agent could be maintained without recurrence of the skin lesions. Topical therapy remains a good option in selected, mild-to-moderate cases of induced bullous pemphigoid.


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