Indian Journal of Dermatology
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E-IJD® - CASE REPORT
Year : 2019  |  Volume : 64  |  Issue : 3  |  Page : 251

Primary cutaneous neuroendocrine carcinoma with diffuse expression of thyroid transcription factor-1: Report of two cases


Department of Dermatology, General Hospital of Valencia, Valencia, Spain

Correspondence Address:
Dr. Jose Maria Ortiz Salvador
Avenida Tres Cruces n°2, 46014 Valencia
Spain
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijd.IJD_608_16

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Primary cutaneous neuroendocrine carcinoma (PCNC), previously known as Merkel cell carcinoma (MCC), is a rare tumor of the skin with aggressive behavior and poor prognosis. Typically, PCNC is positive for Cytokeratin-20 (CK20) and negative for Thyroid Transcription Factor-1 (TTF-1). Rarely, CK-20 negative and TTF-1 positive PCNC have been described. We present the case of two patients with skin lesions histologically compatible with MCCs and a behavior characteristic of this disease, but with expression of TTF-1 instead of CK-20. In conclusion, there are increasing reports of TTF1+ CK20− skin lesions without signs of systemic disease which behave clinically and prognostically like a PCNC. The origin of these TTF1 tumors are, to date, unknown.


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