Indian Journal of Dermatology
  Publication of IADVL, WB
  Official organ of AADV
Indexed with Science Citation Index (E) , Web of Science and PubMed
 
Users online: 1419  
Home About  Editorial Board  Current Issue Archives Online Early Coming Soon Guidelines Subscriptions  e-Alerts    Login  
    Small font sizeDefault font sizeIncrease font size Print this page Email this page
E-IJD«-SHORT COMMUNICATION
Year : 2019  |  Volume : 64  |  Issue : 3  |  Page : 250

Effective healing of leprosy chronic plantar ulcers by application of human amniotic membrane stem cell secretome gel


1 Clinical Department, Faculty of Medicine, Universitas Surabaya (UBAYA), Surabaya, Indonesia
2 Department of Dermato-Venereology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo Teaching Hospital, Surabaya, Indonesia
3 Stem Cell Research and Development Center; Virology and Immunology Laboratory, Department of Microbiology, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia

Correspondence Address:
Dr. C RS Prakoeswa
Department of Dermato-Venereology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo Teaching Hospital, Surabaya
Indonesia
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijd.IJD_6_17

Rights and Permissions

Background: Chronic plantar ulcers are common problems for leprosy patients with numb feet due to their prolonged healing time. Chronic plantar ulcers affect the quality of life of patients and can lead to more serious complications, such as disability and deformity, if not handled appropriately. Wound-care products in the market, however, give unsatisfactory results. One factor in the delayed healing of chronic plantar ulcers due to leprosy is the lack of growth factors and cytokines in the wound due to reduced blood supply. We speculated that application of human amniotic membrane stem cellá(hAMSC) secretome, which contains growth factors and cytokines, could improve wound healing. Aim: To evaluate the effect of topical application of a hAMSC secretome gel on wound healing of chronic plantar ulcers due to leprosy. Materials and Methods: We recruited 11ápatients after leprosy treatment with chronic plantar ulcers due to leprosy. hAMSC secretome gel was applied topically to ulcers every 3ádays for up to 2ámonths. Ulcer size and possible side effects or complications from gel application were evaluated weekly. Results: The ulcers of 8 of 11ápatientsá(72.7%) completely healed, the ulcers of 2ápatientsá(18.2%) partially healed, and the ulcers of 1ápatientá(9.1%) persisted. No ulcers became worse. Conclusion: hAMSC secretome was found to be an efficacious and well-tolerated alternative therapy for chronic plantar ulcers due to leprosy.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed399    
    Printed7    
    Emailed0    
    PDF Downloaded24    
    Comments [Add]    

Recommend this journal