Indian Journal of Dermatology
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ORIGINAL ARTICLE
Year : 2018  |  Volume : 63  |  Issue : 4  |  Page : 297-300
The measurement of serum tumor necrosis factor-alpha levels in patients with lichen planus


Department of Dermatology, Ufuk University, Ankara, Turkey

Date of Web Publication9-Jul-2018

Correspondence Address:
Dr. Yesim Akpinar Kara
Department of Dermatology, Ufuk University, Mah, No 1, Ankara 06510
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijd.IJD_474_17

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   Abstract 


Background: Lichen planus is a common mucocutaneous inflammatory skin disease with a multifactorial etiology. Cytokines have a key role in its pathogenesis. In our study, we aimed to investigate the relationship between the disease severity and levels of the tumor necrosis factor alpha (TNF-α) cytokine which was considered as a primary cytokine that initiates the cytotoxicity. Materials and Methods: A total of 34 patients with lichen planus who were 18 year or older and gender-matched healthy controls were included in the study. Serum TNF-α levels were measured by human TNF-α enzyme-linked immunosorbent assay test kits and the values in the two groups were statistically compared. Results: The mean serum TNF-α levels were higher in the patient group than that in the control group. Serum TNF-α levels were not associated with oral mucosal involvement and gender. However, it was observed that the level of TNF-α was higher in older ages, both in patient and in control groups. Conclusion: It is thought that TNF-α, a proinflammatory cytokine, may have an important role in the pathogenesis of lichen planus.


Keywords: Cytokines, lichen planus, tumor necrosis factor alpha


How to cite this article:
Kara YA. The measurement of serum tumor necrosis factor-alpha levels in patients with lichen planus. Indian J Dermatol 2018;63:297-300

How to cite this URL:
Kara YA. The measurement of serum tumor necrosis factor-alpha levels in patients with lichen planus. Indian J Dermatol [serial online] 2018 [cited 2019 Jun 27];63:297-300. Available from: http://www.e-ijd.org/text.asp?2018/63/4/297/236226


This articles has been retracted due to duplicate publication of the same article by the same author, published in Acta Dermatovenerol APA, on pages 85-88, Issue 4, Volume 26, 2017.






 

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