Indian Journal of Dermatology
  Publication of IADVL, WB
  Official organ of AADV
Indexed with Science Citation Index (E) , Web of Science and PubMed
 
Users online: 382  
Home About  Editorial Board  Current Issue Archives Online Early Coming Soon Guidelines Subscriptions  e-Alerts    Login  
    Small font sizeDefault font sizeIncrease font size Print this page Email this page


 
Table of Contents 
E-IJD CORRESPONDENCE
Year : 2015  |  Volume : 60  |  Issue : 4  |  Page : 424
Bowen's disease of the nipple and areola in an old man


Department of Dermatology, Fukushima Medical University, Fukushima, Japan

Date of Web Publication10-Jul-2015

Correspondence Address:
Masato Ishikawa
Department of Dermatology, Fukushima Medical University, Fukushima
Japan
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5154.160543

Rights and Permissions



How to cite this article:
Ishikawa M, Ohtsuka M, Yamamoto T. Bowen's disease of the nipple and areola in an old man. Indian J Dermatol 2015;60:424

How to cite this URL:
Ishikawa M, Ohtsuka M, Yamamoto T. Bowen's disease of the nipple and areola in an old man. Indian J Dermatol [serial online] 2015 [cited 2019 Aug 17];60:424. Available from: http://www.e-ijd.org/text.asp?2015/60/4/424/160543


Sir,

Bowen's disease (squamous cell carcinoma in situ) usually develops on sun-exposed areas and its occurrence on the breast is rare. We herein describe a case of Bowen's disease of the nipple and areola in an old man.

A 76-year-old man visited our department, complaining of a plaque on his right breast that had been first noted some years previously, and had enlarged slowly. He had no significant medical history. He denied previous histories of treatment with arsenic containing drugs. Also, he had neither occupational exposure suggestive of arsenic toxicity nor history of chronic arsenicism in his neighborhood or family via ground water poisoning. The lesion was a slightly keratotic, irregularly elevated, well-circumscribed, and sized 26 × 19 mm brownish plaque [Figure 1]. The base of the firm tumor was not adhesive to the underling tissue. The right axillary lymph nodes were not palpable. A biopsy specimen showed irregular epidermal hyperplasia and diffuse interstitial infiltration at the papillary dermis [Figure 2]. Most of the inflammatory cells were lymphocytes. In the epidermis, there were many anaplastic keratinocytes with nuclei of irregular size and form. We also found clumping cells and dyskeratotic cells, and many atypical mitotic figures. The basement membrane was not invaded. Results of immunohistochemistry showed strong expression of 34βE-12, and moderate expression of AE1/AE3 and p63 [Figure 3]. Other markers, such as CK7, CK20, CEA, GCDFP-15, and CAM5.2, were all negative. The residual tumor was totally removed with a 5-mm margin under local anesthesia.
Figure 1: Nipple lesion of the right breast

Click here to view
Figure 2: Histological features show irregular hyperplasia of the epidermis, and many of anaplastic keratinocytes, clumping cells, dyskeratotic cells, and atypical mitotic figures (hematoxylin and eosin stain). The basement membrane was not invaded

Click here to view
Figure 3: Immunohistochemistry showing positive findings of p63

Click here to view


Kossard and Rosen reported that the most common site of Bowen's disease was head and neck (440 among 1,001 cases of Bowen's disease), and that the least common site was the torso (65/1001). [1] It is especially rare for Bowen's disease to develop on the nipple. To date, only six cases of Bowen's disease involving the nipple have been reported including our case. [2],[3],[4],[5],[6] The age of patients ranged from 41 to 84-years-old, and male patient was observed in only three cases including our case. Our case was unique in that Bowen's disease occurred involving the nipple and areola in an elderly male patient.

Histological features of Bowen's disease of the nipple and mammary Paget's disease are sometimes similar, but treatments of them are decisively different. It is therefore very important to differentiate those diseases. Immunohistochemical findings are useful for differentiation. Irregular epidermal hyperplasia is a histological feature of Bowen's disease, and that of mammary Paget's disease is clear cells (Paget cell) that sometimes conglomerates in the epidermis. Immunohistochemically, neoplastic cells are positive for p63 and 34βE-12 in Bowen's disease, while Paget cells are positive for CEA, CAM5.2, and GCDFP-15. Thus, in many cases, it is not so difficult to differentiate these two diseases. However, the same is not true for Pagetoid Bowen's disease, a subtype of Bowen's disease. Pagetoid Bowen's disease shows clear cells in epidermis which increase and form conglomerates, but clear cells are not always seen in Pagetoid Bowen's disease, unlike Paget's disease. As the immunohistochemical findings of Pagetoid Bowen's disease are the same as those of Bowen's disease, examination by using antibodies; in particular against p63, GCDFP-15, and 34βE-12; is useful and important for differentiation of those diseases. In conclusion, we presented with a case of Bowen's disease arising on a rare site, and successfully treated by surgical operation.

 
   References Top

1.
Kossard S, Rosen R. Cutaneous Bowen′s disease. An analysis of 1001 cases according to age, sex, and site. J Am Acad Dermatol 1992;27:406-10.  Back to cited text no. 1
    
2.
Cremer H, Paulussen F. Bowen′s disease of the nipple. Geburtshilfe Frauenheilkd 1982;42:590-2.  Back to cited text no. 2
    
3.
Venkataseshan VS, Budd DC, Un Kim D, Hutter RV. Intraepidermal squamous carcinoma (Bowen′s disease) of the nipple. Hum Pathol 1994;25:1371-4.  Back to cited text no. 3
    
4.
Brookes PT, Jhawar S, Hinton CP, Murdoch S, Usman T. Bowen′s disease of the nipple: A new method of treatment. Breast 2005;14:65-7.  Back to cited text no. 4
    
5.
Wei KJ, Lee JY, Wong TW. Immediate nipple-areola reconstruction following excision of Bowen′s disease. Dermatol Sinica 2006;24:275-7.  Back to cited text no. 5
    
6.
Sharma R, Iyer M. Bowen′s disease of the nipple in a young man with AIDS: A case report. Clin Breast Cancer 2009;9:53-5.  Back to cited text no. 6
    


    Figures

  [Figure 1], [Figure 2], [Figure 3]



 

Top
Print this article  Email this article
 
 
  Search
 
  
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Article in PDF (2,244 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  


    References
    Article Figures

 Article Access Statistics
    Viewed1867    
    Printed12    
    Emailed0    
    PDF Downloaded39    
    Comments [Add]    

Recommend this journal