Indian Journal of Dermatology
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E-IJD CASE REPORT
Year : 2015  |  Volume : 60  |  Issue : 4  |  Page : 423

Acral acanthosis nigricans in a case of scleroderma


Department of Dermatology, Venereology and Leprosy, Grant Government Medical College and Sir Jamsetjee Jeejebhoy Group of Hospitals, Mumbai, Maharashtra, India

Correspondence Address:
Dr. Mahendra M Kura
Department of Dermatology, Venereology and Leprosy, Grant Government Medical College and Sir Jamsetjee Jeejebhoy Group of Hospitals, Byculla, Mumbai - 400 008, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5154.160540

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Acanthosis nigricans (AN) is a dermatosis characterized by velvety, papillomatous, brownish-black, hyperkeratotic plaques, typically on the intertriginous surfaces and neck. The majority (80%) of AN occurs idiopathically or in benign conditions such as endocrinopathies like diabetes mellitus, polycystic ovary syndrome; metabolic syndrome and/or heritable disease. Malignancy-associated AN is rare. AN may rarely be associated with autoimmune diseases including systemic lupus erythematosus, due to antibodies to the insulin receptor, so-called type B insulin resistance. Here we report a case of AN in a case of diffuse progressive systemic sclerosis without evidence of insulin resistance.


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