Indian Journal of Dermatology
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E-IJD CURRENT PERSPECTIVE
Year : 2015  |  Volume : 60  |  Issue : 2  |  Page : 212

Tumor-infiltrating CD8+ lymphocytes effect on clinical outcome of muco-cutaneous melanoma


1 Department of surgical Pathology, Kermanshah Medical University, Kermanshah, Iran
2 Department of Dermathopatology, Tehran Medical University, Kermanshah, Iran
3 Department of Dentistry, Dentist, Kermanshah Dentistry University, Kermanshah, Iran
4 Medical student (Intern), Iran Medical University, Tehran, Iran

Correspondence Address:
Mahtab Rahbar
Department of surgical Pathology, Kermanshah Medical University, Kermanshah
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5154.152571

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Background: Recent data have changed our views of prognostic factors in cutaneous melanoma, while some newer methods have yielded better prognostic information. Tumor-infiltrating lymphocytes are believed to represent the immune reaction/response to melanoma cells which is often found in melanocytic cancer. Aim and Objective: We carried out an analysis, aiming to establish pooled estimates for clinical outcomes based on the presence of CD8+ T cell in melanocytic cancer. Materials and Methods: We have included 42 patients with primary cutaneous melanocytic cancer without preoperative treatments in our study. We next analyzed the proliferative activity of CD8+ T cells that infiltrated in tumor cell nests. The intratumoral and adjacent to invasive margin of tumor CD+ T-cell infiltration were analyzed which could also reflect antitumor immunity. Results: The total number of CD8+ cells especially adjacent to invasive margin of tumor was positively correlated with anatomical tumor thickness (P < .001) and not correlated with patient's age and sex. The stage of tumor which is related to vascular-neural invasion, regional lymph nodes involvement and tumor thickness shows positive correlation with CD8+ infiltration in tumor (P < .004, P < .005, P < .001), respectively. Acral melanoma shows more CD8 lymphocytes infiltration and also recurrence rate of tumor (P < .005). Conclusion: We believe that CD8+ T-cell infiltration in primary cutaneous melanocytic cancer represents the immune reaction/response to melanoma which could be an important new therapy for melanoma although more research is needed on this treatment modality.


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