Indian Journal of Dermatology
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E-IJD BASIC RESEARCH
Year : 2015  |  Volume : 60  |  Issue : 2  |  Page : 211

G-231A and G+70C polymorphisms of endothelin receptor type-A gene could affect the psoriasis area and severity index score and endothelin 1 levels


1 Medical Park Bahçelievler Hospital, Dermatology Clinic, Istanbul, Turkey
2 Department of Biochemistry, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
3 Okmeydani Research and Training Hospital, Istanbul, Turkey
4 Department of Biochemistry, Medical Park Bahçelievler Hospital, Istanbul, Turkey

Correspondence Address:
Pervin Vural
Department of Biochemistry, Çapa 34093, Istanbul
Turkey
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Source of Support: Research Fund of the University of Istanbul (Project No. 9727), Conflict of Interest: None


DOI: 10.4103/0019-5154.152561

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Background: The etiopathogenesis of psoriasis has not been clearly elucidated although the role of chronic inflammation, imbalance between pro- and anti-inflammatory cytokines, and many immunological events have been established. Endothelin 1 (EDN1) and endothelin receptor type-A (EDNRA) are implicated in the inflammatory process. The relationships between EDN1 and EDNRA polymorphisms with several diseases have been found. Aims and Objectives: This study examined the possible association of EDN1 (G5665T and T-1370G) and EDNRA (G-231A and G + 70C) single nucleotide polymorphisms (SNPs) with the occurence of psoriasis, and evaluated the relationship between genotypes and clinical/laboratory manifestation of psoriasis. Materials and Methods: We analyzed genotype and allele distributions of the above-mentioned polymorphisms in 151 patients with psoriasis and 152 healthy controls by real-time PCR combined with melting curve analysis. Results: We did not find significant differences in the genotype and allele distributions of EDN1 T-1370G, EDNRA G-231A, and EDNRA G+70C polymorphisms between patients with psoriasis and healthy controls. Psoriasis area and severity index (PASI) score of EDNRA -231 polymorphic A allele carrying subjects (AA and AA + AG) was higher than that of wild homozygotes (P = 0.044 and P = 0.027, respectively). In addition, EDN1 levels in EDNRA+70 polymorphic C allele carriers (CC + CG) were elevated when compared with GG genotype; however, the difference was at borderline significance (P = 0.05). Conclusion: Although there were no associations between studied polymorphisms and psoriasis susceptibility, the PASI score and EDN1 levels seem to be affected by EDNRA G-231A and G + 70C polymorphisms.


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