Indian Journal of Dermatology
  Publication of IADVL, WB
  Official organ of AADV
Indexed with Science Citation Index (E) , Web of Science and PubMed
 
Users online: 3070  
Home About  Editorial Board  Current Issue Archives Online Early Coming Soon Guidelines Subscriptions  e-Alerts    Login  
    Small font sizeDefault font sizeIncrease font size Print this page Email this page
E-IJD ORIGINAL ARTICLE
Year : 2015  |  Volume : 60  |  Issue : 2  |  Page : 211

Role of interleukin-2 in uremic pruritus among attendants of Al-Zahraa hospital dialysis unit


1 Department of Dermatology and Venereology, Al Azhar University, Cairo, Egypt
2 Department of Community Medicine, Al Azhar University, Cairo, Egypt
3 Department of Clinical Pathology, Al Azhar University, Cairo, Egypt

Correspondence Address:
Amira Adel Abdel Azim
6 Amin Zaki Street., 4th quarter Heliopolis, Post code: 11341, Cairo
Egypt
Login to access the Email id

Source of Support: Researchers personal financial, Conflict of Interest: None


DOI: 10.4103/0019-5154.152565

Rights and Permissions

Background: Uremic pruritus (UP) is a very distressing symptom and remains one of the most frustrating and potentially disabling symptoms in patients with end-stage renal disease (ESRD). Its etiopathogenesis remains unclear and complex. The aim of this study was to investigate the possible role of interleukin-2 (IL-2) in UP, and correlate its level with the severity of itching in ESRD patients. Patients and Methods: This study was carried out on 60 patients on maintenance hemodialysis (HD), 30 patients with UP and 30 patients without UP, and 30 apparently healthy age- and sex-matched subjects as controls. Itch intensity was scored as mild, moderate, and severe using five-dimensional itch scale. Some relevant clinical parameters (age, sex, xerosis, presence of neuropathy, duration of dialysis, complete medical history, and history of pruritic skin diseases) and laboratory findings including creatinine, urea, calcium, phosphorus, parathyroid hormone, and serum levels of IL-2 were evaluated. Results: In our study, we found a statistically significant difference in IL-2 level between patients and controls. However, there was no statistically significant difference in IL-2 levels between cases with pruritus and cases without pruritus. Also, there was a statistically significant relation between IL-2 level and duration of the disease. Conclusion: Further studies are needed to understand the contribution of IL-2 and possibly other cytokines in the pathogenesis of this distressing symptom in ESRD.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2745    
    Printed32    
    Emailed1    
    PDF Downloaded35    
    Comments [Add]    

Recommend this journal