Indian Journal of Dermatology
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Year : 2013  |  Volume : 58  |  Issue : 5  |  Page : 406

Erythema nodosum as azathioprine hypersensitivity reaction in a patient with bullous pemphigoid

1 Department of Internal Medicine, Systemic Autoimmune Diseases Unit, Virgen de Las Nieves University Hospital, Granada, Spain
2 Department of Dermatology, Virgen de Las Nieves University Hospital, Granada, Spain

Correspondence Address:
Jose Antonio Vargas-Hitos
Internal Medicine Department, Virgen de las Nieves University Hospital, 9th floor, Avda. Fuerzas Armadas No 2, Granada 18014
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5154.117332

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A 65-year-old woman with bullous pemphigoid presented with fever and several red-purple nodular subcutaneous lesions on both lower legs 1 week after starting treatment with azathioprine (AZA). Biopsy of a skin nodule was compatible with erythema nodosum (EN) and hypersensitivity reaction to AZA was suspected. AZA was subsequently discontinued, observing complete remission of fever and EN within 2 weeks. This case highlights the importance of recognizing EN as a possible manifestation of hypersensitivity reaction to AZA.

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