Indian Journal of Dermatology
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Year : 2013  |  Volume : 58  |  Issue : 5  |  Page : 380-382

Docetaxel-induced hand and foot syndrome in a patient with metastatic breast carcinoma

1 Department of Dermatology, Apollo Speciality Cancer Hospital, Anna salai, Chennai, India
2 Department of Medical Oncology, Apollo Speciality Cancer Hospital, Anna salai, Chennai, India

Correspondence Address:
Ravichandran Gurumurthi
Apollo Speciality Cancer Hospital, Padma Complex, 320, Anna Salai, Chennai - 600 035
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5154.117309

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Hand and foot syndrome (HFS) is a well-known complication of chemotherapeutic drugs given in a dose-dense manner. Our patient was a 52-year-old female with metastatic breast carcinoma on salvage chemotherapy regimen with docetaxel at a dose of 60 mg/m 2 . The patient had grade 3 HFS characterized by symmetrical, tender, and erythematous skin lesions over the palms and soles associated with dysesthesia necessitating interruption of treatment. She developed this syndrome at a much lower dose than previously described due to her altered hepatic function. An insight regarding this unique distressing side-effect and assessment of various contributing factors would help us identify and treat the patient at the earliest.

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