Indian Journal of Dermatology
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Year : 2013  |  Volume : 58  |  Issue : 4  |  Page : 325

Reduced P53 staining in actinic keratosis is associated with squamous cell carcinoma: A preliminary study

1 Department of Dermatology, Federal University of São Paulo- SP, Brazil
2 Department of Pathology, Federal University of São Paulo- SP, Brazil
3 Department of Genetics and Evolution, Federal University of São Carlos - SP, Brazil

Correspondence Address:
D R Neto Pimentel
Rua Guilherme Bannitz, 55 CJ 601, São Paulo-Brazil, CEP 04532-060
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5154.113935

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Background : Actinic keratosis (AK) is a cutaneous neoplasm caused by prolonged sun exposure, and may progress into squamous cell carcinoma (SCC). The p53 gene plays a central role in the development of SCC, and mutations in this gene are found in 90% of SCC and up to 100% of AK cases. Objective: To identify AK cases that are highly susceptible to developing SCC. Materials and Methods: Fifty-six AK cases were classified into two groups: AK adjacent to "normal" skin and AK adjacent to SCC. The groups were compared based on epithelial atypia, inflammation, solar elastosis, histopathological AK classification and p53 protein expression. Results: Of the 56 AK cases analyzed, 23% were associated with SCC. The types of AK observed were classified as follows: common, hypertrophic , atrophic , acantholytic , pigmented and bowenoid . SCC was associated with common and hypertrophic AK, and p53 staining was observed in 78% of AK cases. The mean difference in p53 immunopositivity between common AK cases associated with SCC (17%) and not associated with SCC (45.4%) was significant (p=0.011). Conclusions: Hypertrophic and common AK are associated with SCC, and the low percentage of p53 immunopositivity in the common type indicates a greater probability of developing into SCC.

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