Indian Journal of Dermatology
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E-REVIEW ARTICLE
Year : 2013  |  Volume : 58  |  Issue : 2  |  Page : 157

Macrophage migration inhibitory factor as an incriminating agent in dermatological disorders


1 Department of Dermatology, Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Department of Dermatology, Jahrom University of Medical Sciences, Jahrom, Iran

Correspondence Address:
Amir Feily
Department of Dermatology, Jahrom University of Medical Sciences, Jahrom
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5154.108068

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Macrophage migration inhibitory factor (MIF) is a critical immunoregulatory pluripotent cytokine. It has been re-evaluated as a proinflammatory cytokine, pituitary hormone and glucocorticoid-induced immunoregulatory protein. MIF exists in human epidermis, especially in the basal layer and also is expressed constitutively by monocytes/macrophages, T cells, B cells, endocrine, and epithelial cells. In the field of dermatology, MIF is believed to be a detrimental factor in inflammatory dermatological diseases including atopic dermatitis (AD), psoriasis, vitiligo, pemphigus vulgaris, bullous pemphigoid (BP), alopecia areata (AA) as well as other conditions such as photoaging, and photocarcinigenesis. The objective of this review is to gather and summarize MIF related disorders in dermatology and present valuable information for readers and researchers.


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