Indian Journal of Dermatology
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THERAPEUTIC ROUND
Year : 2012  |  Volume : 57  |  Issue : 2  |  Page : 123-125

Treatment of cutaneous lesion of 20 years' duration caused by leishmanization


1 Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran
2 Nanotechnology and Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Correspondence Address:
Ali Khamesipour
Center for Research and Training in Skin Diseases and Leprosy, Medical Sciences/University of Tehran, P.O. Box 14155-6383, Tehran 14166
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5154.94280

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The inoculation of live Leishmania (L.) major to produce a single lesion is called leishmanization (LZ). LZ lesion upon cure prevents further natural infection which might be multiple lesions on unwanted sites such as face. Cutaneous leishmaniasis (CL) usually leads to a self healing lesion; though rarely the lesion persists and becomes refractory to all types of remedies. Here, we present a 41-year-old patient with a 20-year history of cutaneous lesion caused by leishmanization. The causative agent is identified as L. major. The patient did not respond to treatment with meglumine antimoniate, 20 mg/kg/day Sb +5 for three weeks and allopurinol 10 mg/kg for four weeks. After two months, the same treatment was repeated. In addition, a topical liposomal preparation containing 10% paromomycin sulfate was administered twice a day for four weeks. The lesion showed marked improvement during the treatment and was eventually completely healed.


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