Indian Journal of Dermatology
  Publication of IADVL, WB
  Official organ of AADV
Indexed with Science Citation Index (E) , Web of Science and PubMed
 
Users online: 1128  
Home About  Editorial Board  Current Issue Archives Online Early Coming Soon Guidelines Subscriptions  e-Alerts    Login  
    Small font sizeDefault font sizeIncrease font size Print this page Email this page
BASIC RESEARCH
Year : 2012  |  Volume : 57  |  Issue : 1  |  Page : 9-11

Allogenic hematopoietic stem cell transplantation in pemphigus vulgaris: A single-center experience


1 Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases and Research Centre (IKDRC) and Dr. H. L. Trivedi Institute of Transplantation Sciences (ITS), Ahmedabad, India
2 Department of Nephrology and Clinical Transplantation, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases and Research Centre (IKDRC) and Dr. H. L. Trivedi Institute of Transplantation Sciences (ITS), Ahmedabad, Gujarat, India
3 Department of Urology and Transplantation Surgery, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases and Research Centre (IKDRC) and Dr. H. L. Trivedi Institute of Transplantation Sciences (ITS), Ahmedabad, Gujarat, India
4 Department of Anesthesia and Critical Care, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases and Research Centre (IKDRC) and Dr. H. L. Trivedi Institute of Transplantation Sciences (ITS), Ahmedabad, Gujarat, India

Correspondence Address:
Aruna V Vanikar
Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, Institute of Kidney Diseases and Research Centre (IKDRC) and Institute of Transplantation Sciences (ITS), Civil Hospital Campus, Asarwa, Ahmedabad - 380 016, Gujarat
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5154.92667

Rights and Permissions

Background: Pemphigus vulgaris (PV), an autoimmune disorder characterized by blistering skin/mucus membrane lesions, is mediated by desmoglein-3 autoantibodies. We carried out a prospective clinical trial of hematopoietic stem cell transplantation (HSCT) in thymus, bone marrow (BM) and periphery to reconstitute central and peripheral arms of self-tolerance. Materials and Methods: Eleven (M:F=5:6) patients with mean age 33.5 years and mean duration of disease 22.8 months, having painful pruritic blisters and ulcers resistant to corticosteroids, were treated with cytokine-stimulated allogeneic HSCT (mean dose: 21.8 Χ 10 8 cells/kg BW) from blood group-matched related donors. BM with mean CD34+ count 1.1% was inoculated into thymus, marrow and periphery, followed by two peripheral blood stem cell (PBSC) infusions. Results: Recovery began within 24 hours of HSCT and new lesions stopped after 6 months. No graft versus host disease (GvHD)/adverse effect was observed in any patient/donor. Over a mean follow-up of 8.02 years, all patients were well without recurrence/new lesions. Conclusion: Drug-resistant PV can be successfully and safely treated by allogeneic HSCT.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3531    
    Printed124    
    Emailed0    
    PDF Downloaded90    
    Comments [Add]    
    Cited by others 3    

Recommend this journal