Indian Journal of Dermatology
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THERAPEUTIC ROUND
Year : 2011  |  Volume : 56  |  Issue : 5  |  Page : 515-516

Oral itraconazole for the treatment of severe seborrhoeic dermatitis


1 Department of Dermatology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India
2 Department of Microbiology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India

Correspondence Address:
Jayasree Nath
Department of Dermatology, Calcutta School of Tropical Medicine, CR Avenue, Kolkata - 700 073, West Bengal
India
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DOI: 10.4103/0019-5154.87137

PMID: 22121267

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Background : Seborrheic dermatitis (SD) is an inflammatory skin disorder in which colonies of Malassezia furfur have been found in affected areas. Aim: The aim of this study was to evaluate the efficacy of itraconazole in the treatment of severe SD. Materials and Methods: Itraconazole was given to 30 patients of SD in a dose of 100 mg twice daily for 1 week followed by 200 mg/day for first 2 days of the following 2 months. The response was noted on day 15, 30, 60, and 90. The clinical response was graded as markedly effective, effective, or ineffective. Results: Clinical improvement (evaluated as markedly effective or effective) was observed in 83.3% cases. Conclusion : The anti-inflammatory activity of oral itraconazole suggests that it should be the first-line therapy in severe SD.


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