Indian Journal of Dermatology
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BASIC RESEARCH
Year : 2011  |  Volume : 56  |  Issue : 5  |  Page : 497-500

HLA-A and HLA-B alleles associated in psoriasis patients from Mumbai, Western India


1 National Institute of Immunohaematology, Indian Council of Medical Research, 13th Floor, K.E.M. Hospital, Parel, Mumbai, India
2 Department of Dermatology, Seth G.S. Medical College, K.E.M. Hospital, Parel, Mumbai, India

Correspondence Address:
Shankarkumar Umapathy
Scientist "D", National Institute of Immunohaemtology, 13th Floor, KEM Hospital, Parel, Mumbai - 400 012, Maharashtra
India
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DOI: 10.4103/0019-5154.87128

PMID: 22121262

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Background: Psoriasis, a common autoimmune disorder characterized by T cell-mediated keratinocyte hyperproliferation, is known to be associated with the presence of certain specific Human Leukocyte Antigen (HLA) alleles. Aim: To evaluate distribution of HLA-A and HLA-B alleles and hence identify the susceptible allele of psoriasis from patients in Western India. Materials and Methods: The study design included 84 psoriasis patients and 291 normal individuals as controls from same geographical region. HLA-A and HLA-B typing was done using Serology typing. Standard statistical analysis was followed to identify the odds ratio (OR), allele frequencies, and significant P value using Graphpad software. Results: The study revealed significant increase in frequencies of HLA-A2 (OR-3.976, P<0.0001), B8 (OR-5.647, P<0.0001), B17 (OR-5.452, P<0.0001), and B44 (OR-50.460, P<0.0001), when compared with controls. Furthermore, the frequencies of HLA-A28 (OR-0.074, P=0.0024), B5 (OR-0.059, P<0.0001), B12 (OR-0.051, P=0.0002), and B15 (OR-0.237, P=0.0230) were significantly decreased in psoriasis patients. Conclusion: This study shows the strong association of HLA-A2, B8, and B17 antigens with psoriasis conferring susceptibility to psoriasis patients from Western India, while the antigens HLA-A28, B5, and B12 show strong negative association with the disease.


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