Indian Journal of Dermatology
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CME ARTICLE
Year : 2011  |  Volume : 56  |  Issue : 5  |  Page : 480-484

Hypothesis: Zinc can be effective in treatment of vitiligo


Department of Dermatology, Jundishapour University of Medical Sciences, Ahvaz, Iran

Correspondence Address:
Nooshin Bagherani
Department of Dermatology, Emam Khomeini Hospital, 61335, Ahvaz
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5154.87116

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Vitiligo is a common depigmenting skin disorder (prevalence 0.1-2%), still represents a cause of stigmatization and quality of life impairment in a large population. Several theories on vitiligo etiopathogenesis have been suggested including in trauma, stress, and autoimmune and genetic predisposition, accumulation of toxic compounds, altered cellular environment, imbalance in the oxidant-antioxidant system, impaired melanocyte migration and/or proliferation, infection, and psychological factors. Zinc, as a trace element, has many vital functions in human. It is antiapoptotic factor and needed as a cofactor for antioxidant defense system. It plays an important role in the process of melanogenesis. It may be effective in prevention and treatment of vitiligo via some mechanism. Herein, we suggested some probable protective mechanism for zinc in association with vitiligo.


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