Indian Journal of Dermatology
  Publication of IADVL, WB
  Official organ of AADV
Indexed with Science Citation Index (E) , Web of Science and PubMed
 
Users online: 1796  
Home About  Editorial Board  Current Issue Archives Online Early Coming Soon Guidelines Subscriptions  e-Alerts    Login  
    Small font sizeDefault font sizeIncrease font size Print this page Email this page
ORIGINAL ARTICLE
Year : 2011  |  Volume : 56  |  Issue : 3  |  Page : 278-281

Uric acid : A new antioxidant in patients with pemphigus vulgaris


1 Skin Research Center, Shohada-e-Tajrish Hospital, Shahid Beheshti Medical University, Tehran, Iran
2 Prevention and Treatment of Obesity, Obesity Research Center, Research Institute for Endocrine Science, Shahid Beheshti Medical University, Tehran, Iran
3 Department of Biostatistics, Faculty of Paramedical Sciences, Shahid Beheshti Medical University, Tehran, Iran

Correspondence Address:
Maryam Yousefi
Skin Research Center, Shohada-e-Tajrish Hospital, Ghods Sq., Shahrdary St., Tehran
Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5154.82480

Rights and Permissions

Background: Increased reactive oxygen species (ROS) and lipid peroxidation are seen in many dermatologic disorders, for example, atopic dermatitis, psoriasis, vitiligo, acne vulgaris, pemphigus vulgaris (PV), lichen planus, and alopecia areata. ROS has an important role in the inflammation process. In PV, increased production of ROS leads to decline of antioxidants in plasma and red blood cells which results in oxidative stress. We aimed to evaluate the level of these antioxidants in PV patients and compare it to the controls. Materials and Methods: Among patients attending the dermatology clinics, 30 patients with PV, who had never been on treatment, were enrolled to the study. The control group consisted of 30 age- and sex-matched healthy non-smoker individuals. Venous blood was collected from the subjects for the evaluation of plasma levels of glutathione peroxidase, vitamin C, selenium, bilirubin, and uric acid. Results: Age mean and standard deviation of the patients (40.83, 12.74) was comparable to the controls (41.96, 13.08). Mean level of uric acid was significantly lower in PV patients compared to the controls (P = 0.006). Other antioxidants were not different between the two groups. Uric acid of the patients with mucosal involvement was significantly lower than patients with mucocutaneous involvement (P = 0.049). Limitations: The blood level of other antioxidants (e.g. malondialdehyde) was not evaluated. Conclusions: Uric acid as an antioxidant in our study had similar changes to previous studies in the field of other diseases but selenium, bilirubin, and glutathione peroxidase did not differ between patients and controls.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3990    
    Printed133    
    Emailed6    
    PDF Downloaded150    
    Comments [Add]    
    Cited by others 10    

Recommend this journal