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Indian Journal of Dermatology
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BASIC RESEARCH
Year : 2011  |  Volume : 56  |  Issue : 3  |  Page : 272-277

Association of cytokine gene polymorphisms with psoriasis in cases from the Nile Delta of Egypt


1 College of Medicine, Qassim University, Qassim, Saudi Arabia;Genetics Unit, Children Hospital, Mansoura University, Mansoura, Egypt
2 Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt
3 Genetics Unit, Children Hospital, Mansoura University, Mansoura, Egypt

Correspondence Address:
Ahmad A Settin
Mansoura University, Mansoura, Egypt; Visiting Prof. Qassim University, BO 6655 Buraydah 51452, Saudi Arabia

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5154.82479

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Background: Psoriasis is a chronic inflammatory skin disease with an immunogenetic background. This work was planned to check for the association of polymorphisms related to cytokine genes TNF-α-308 (G/A), IL-10 -1082 (G/A), IL-6 -174 (G/C), and IL-1Ra (VNTR) with psoriasis in cases from Egypt. Materials and Methods: This work included 46 cases with psoriasis recruited from the Dermatology Departments, University Hospitals, Nile Delta region of Egypt. They included 14 males and 32 females with an age mean ± SD of 46.68 ± 12.16 years and range of 15-70 years. Their genotypes were compared to 98 healthy controls of matched age and sex from the same locality. Genotyping was done through deoxyribonucleic acid amplification using PCR with sequence specific primers for polymorphic alleles. Results: Compared to controls, cases showed significant higher frequency of certain genotypes including IL-6 -174 CC (P < 0.001, OR = 6.7), IL-10 -1082 GG ( P < 0.05, OR = 5.1), and TNF-α-308 GG ( P < 0.05, OR = 3.7). TNF-α-308 GG and IL-10 -1082 GG genotypes were higher among cases with plaque subtype of moderate severity. Combined heterozygosity for IL-10 GA, IL-6 GC with TNF GA showed a significant low frequency among studied cases. Conclusion: Genetic polymorphisms related to IL6, IL10, and TNF-α genes showed a particular pattern of association with psoriasis that may have a potential impact on disease counseling and management.


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