Indian Journal of Dermatology
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REVIEW ARTICLE
Year : 2011  |  Volume : 56  |  Issue : 3  |  Page : 259-261

Pathogenesis of dermatophytoses


Department of Dermatology, Dr. D. Y. Patil Medical College, Pimpri, Pune, India

Correspondence Address:
Ram Tainwala
1001, Swapna-lok tower-1, Marve Road, Malad-west, Mumbai - 64
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5154.82476

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Dermatophytes can survive solely on outer cornified layers of the skin. The ability of certain fungi to adhere to particular host arises from numerous mechanisms and host factors, including the ability to adapt to the human body. Natural infection is acquired by the deposition of viable arthrospores or hyphae on the surface of the susceptible individual. After the inoculation in the host skin, suitable conditions favor the infection to progress through the stages of adherence and penetration. Development of host response is mostly by a T-cell mediated response of delayed-type hypersensitivity. Antibody formation does not seem to be protective. Natural defenses against dermatophytes depend on both immunological and nonimmunological mechanisms.


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