Indian Journal of Dermatology
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Year : 2010  |  Volume : 55  |  Issue : 4  |  Page : 409-410
A 17-year-old woman with bullous lesions


Department of Dermatology, "UMF" Iuliu-Hatieganu, Clinicilor Street, No. 1-3, Cluj-Napoca, Romania

Date of Web Publication4-Jan-2011

Correspondence Address:
Maria Crisan
Department of Dermatology, "UMF" Iuliu-Hatieganu, Clinicilor Street, No. 1-3, Cluj-Napoca
Romania
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5154.74577

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How to cite this article:
Crisan M, Bucur R, Crisan D. A 17-year-old woman with bullous lesions. Indian J Dermatol 2010;55:409-10

How to cite this URL:
Crisan M, Bucur R, Crisan D. A 17-year-old woman with bullous lesions. Indian J Dermatol [serial online] 2010 [cited 2020 May 30];55:409-10. Available from: http://www.e-ijd.org/text.asp?2010/55/4/409/74577


A 17-year-old woman with no significant medical history presented with mildly pruritic vesiculous eruption displayed on her trunk, arms, and scalp with bullae grouped together and isolated, on erythematous base. [Figure 1] and [Figure 2]. On the buccal mucosa there were superficial erosions. On her palms and forearms, she had target-like, erythematous lesions. [Figure 3]. The symptomatology began 8 months ago and its evolution was slow, but progressive.
Figure 1 :Grouped bullous lesions on trunk

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Figure 2 :Grouped bullous lesions below umbilicus

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Figure 3 :Target like erythematous lesions on palm

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Laboratory findings revealed an acute inflammatory syndrome (leukocytosis with neutrophillia, elevated PCR). Biopsies were taken from the lesional skin (for hematoxylin eosin staining), and from apparently normal skin (for direct immunofluorescence). The histological slide evidenced an atrophic epidermis with deep bullae and an increased eosinophilic infiltrate), while the direct immunofluorescence was positive for IgG, IgM, and C3, with band - like deposits along the basement membrane. [Figure 4].
Figure 4 :Showing IgG, IgM, and C3, with band - like deposits along the basement membrane

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   Question Top


What is your diagnosis?



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   References Top

1.Olasz EB, Yancey KB. Bullous pemphigoid and related subepidermal autoimmune blistering diseases. Curr Dir Autoimmun 2008;10:141-66.  Back to cited text no. 1
    
2.Salmhofer W, Kawahara Y, Soyer HP, Kerl H, Nishikawa T, Hashimoto Y. A subepidermal blistering disease with histopathological features of dermatitis herpetiformis and immunofluorescence characteristics of bullous pemphigoid: A novel subepidermal blistering disease or a variant of bullous pemphigoid? Br J Dermatol 1997;137:599-604.  Back to cited text no. 2
    
3.Lamb PM, Abell E, Tharp M, Frye R, Deng JS. Prodromal bullous pemphigoid. Int J Dermatol 2006;45:209-14.  Back to cited text no. 3
    
4.Czernik A, Bystryn JC. Improvement of intravenous immunoglobulin therapy for bullous pemphigoid by adding immunosuppressive agents: Marked improvement in depletion of circulating autoantibodies. Arch Dermatol 2008;144:658-61.  Back to cited text no. 4
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4]



 

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