Indian Journal of Dermatology
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CASE REPORT
Year : 2010  |  Volume : 55  |  Issue : 4  |  Page : 384-386

Pyrazinamide-induced maculopapular rash


1 Department of Epidemiology and Public Health, Lala Ram Sarup Institute of TB & RD, Sri Aurobindo Marg, New Delhi - 110 030, India
2 Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, Hamdard University, New Delhi - 110 062, India
3 Department of Pharmacology, Lala Ram Sarup Institute of TB & RD, Sri Aurobindo Marg, New Delhi - 110 030, India

Correspondence Address:
Faisal Imam
Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, Hamdard University, New Delhi - 110 062
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5154.74562

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Pyrazinamide is a commonly used first-line antitubercular drug. Gastric-related adverse drug reactions are common with pyrazinamide. Dermatological manifestations due to pyrazinamide are rare. This study aimed find out the dermatological manifestations/adverse drug reaction (ADR) due to pyrazinamide. We reported a case of maculopapular rash caused by pyrazinamide in a patient on antituberculosis treatment using structured questionnaires. The patient developed maculopapular rashes on receiving combination antituberculosis treatment. The rashes disappeared after stopping the suspected drug. The patient was rechallenged with pyrazinamide, which led to reappearance of a similar type of rash. The causality, preventability, and severity were assessed using the Naranjo algorithm and Hartwig scale. Since pyrazinamide is a commonly used drug in tuberculosis and which is a common infectious disease in developing countries, with the similar reports, we can predict early case detection and can prevent the occurrence of similar reactions in future.


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