Indian Journal of Dermatology
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CASE REPORT
Year : 2010  |  Volume : 55  |  Issue : 3  |  Page : 259-261

Seronegative necrolytic acral erythema: A distinct clinical subset?


1 Department of Dermatology, KPC Medical College, Kolkata, India
2 Department of Dermatology, Apollo Gleneagles Hospital, Kolkata, India

Correspondence Address:
S Panda
Ashok-Swapna, 122/4, Dr. Jiban Ratan Dhar Road, Kolkata - 700028
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5154.70676

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A patient was referred to us with asymptomatic, erythematous, nonitchy, scaly lesions present bilaterally on the dorsa of his feet and toes since the last 2 months. Both the legs had pitting edema as well. There were hyperkeratosis, focal parakeratosis, acanthosis and scattered spongiosis in the epidermis, and proliferation of capillaries with perivascular infiltration of lymphomononuclear cells in the dermis. There was no serological evidence of hepatitis C virus. Laboratory investigations revealed hypoalbuminemia and low-normal serum zinc. On clinicopathological correlation, we made a diagnosis of necrolytic acral erythema (NAE). The lesions responded dramatically to oral zinc sulfate and topical clobetasol propionate within 3 weeks with disappearance of edema and scaling and only a minimal residual erythema. This is the first reported case of NAE from Eastern India. NAE with negative serology for hepatitis C may be viewed as a distinct subset of the condition that had been originally described.


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