Indian Journal of Dermatology
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BASIC RESEARCH
Year : 2010  |  Volume : 55  |  Issue : 1  |  Page : 25-28

Impact of HLA-G in the outcome of vitiligo in Tunisian patients


1 Research Unit on the Antioxidant Compounds, Oxidative Stress, Trace Elements and Metabolic Diseases, Department of Physiology, Ecole Supérieure des Sciences et Techniques de la Santé de Tunis, Tunisia,
2 Department of Dermatological and Venereal Diseases Hospital Foschi, Suresnes, Paris,
3 Laboratory of Immunogenetics, Department of Immunology Research, France,

Correspondence Address:
Akrem Jalel
Ecole Supérieure des Sciences et Techniques de la Santé de Tunis. BP 176 Bab-Souika, 1006 Tunis, Tunisia

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DOI: 10.4103/0019-5154.60346

PMID: 20418972

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Background: The human leukocyte antigen (HLA) system in the skin coordinates the pigmentation and immune response and could be implicated in the pathogenesis of vitiligo. Human leukocyte antigen HLA-G is a nonclassic, major histocompatibility complex class I molecule expressed in the extravillous cytotrophoblast at the feto-maternal interface. It is known to protect the fetus from maternal cellular immunity. Analogically, it could be implicated in the pathogenesis of autoimmune diseases such as vitiligo. Aims: To compare the expression of HLA-G between vitiligo patients and healthy controls. Materials and Methods: In the present study, 22 vitiligo patients and 24 healthy controls were investigated to look for a possible correlation between HLA-G expression and this pathology. Expression of HLA-G in cutaneous biopsy specimens was investigated by immunohistochemical analysis. Results: HLA-G was detected in the biopsy specimens of 3 (13%) out of 22 patients. This number was significantly higher in healthy controls 18 (75%) out of 24 as compared to vitiligo patients ( P < 0.001). Conclusion: There is significant negative correlation between HLA-G expression and vitiligo. In our mind, upregulation of HLA-G expression in lesional skin could be local (superficial expression) or systemic (soluble HLA-G isoforms) compensation to restore normal pigmentation in lesions.


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