Indian Journal of Dermatology
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CASE REPORT
Year : 2009  |  Volume : 54  |  Issue : 5  |  Page : 66-67

Cefoperazone induced hypersensitivity vasculitis


Department of Tuberculosis and Respiratory Diseases, GSVM Medical College, Kanpur, India

Correspondence Address:
Shivesh Prakash
Department of Tuberculosis and Respiratory Diseases, Dr. ML Chest hospital, GSVM Medical College, Kanpur
India
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Source of Support: None, Conflict of Interest: None


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Cefoperazone has been reported to cause vasculitic complications only once before. Here, we report yet another case of hypersensitivity vasculitis associated with cefoperazone. A 28-year-old lady with pneumococcal pneumonia developed hypersensitivity vasculitis on the fifth day of cefoperazone therapy. Hypersensitivity vasculitis resolved gradually after removal of the agent and did not recur. Although hypersensitivity vasculitis has multiple causes, coexistence of hypersensitivity vasculitis and cefoperazone treatment, and the quick resolution of the disease after removal of the drug, strongly favors a causative relationship. To our knowledge, this is the second report of a hypersensitivity vasculitis associated with cefoperazone and hence the drug should be considered as a possible cause while evaluating a case of drug induced hypersensitivity vasculitis.


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