Indian Journal of Dermatology
  Publication of IADVL, WB
  Official organ of AADV
Indexed with Science Citation Index (E) , Web of Science and PubMed
 
Users online: 223  
Home About  Editorial Board  Current Issue Archives Online Early Coming Soon Guidelines Subscriptions  e-Alerts    Login  
    Small font sizeDefault font sizeIncrease font size Print this page Email this page
THERAPEUTIC ROUND
Year : 2009  |  Volume : 54  |  Issue : 4  |  Page : 357-360

Vitiligo treatment with vitamins, minerals and polyphenol supplementation


1 Unité de Recherche sur les Composés Antioxydants, Stress Oxydant, Eléments Traces et Maladies Métaboliques, Ecole Supérieure des Sciences et Techniques de la Santé de Tunis, Tunisia
2 Service d'anatomie-pathologie et d'Embryologie Departement de Foetopathologie, CHU-Centre de Maternité et de Néonatologie de Tunis., Tunisia

Correspondence Address:
Akrem Jalel
Ecole Supérieure des Sciences et Techniques de la Santé de Tunis. BP 176 Bab- Souika 1006 Tunis
Tunisia
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5154.57613

Rights and Permissions

Background: Mammalian pigmentation results from the synthesis and accumulation of photo protective epidermal melanin. Melanin was formed from the amino acid precursor L-tyrosine within specialized cells, the melanocytes. Oxidative stress has been suggested to be the initial pathogenetic event in melanocyte degeneration with H 2 O 2 accumulation in the epidermis of patients with active disease. Auto immunity has been also suggested as another hypothesis in the pathogenesis of depigmentation disorders. Topical corticosteroids and phototherapy as common treatment modalities have been prescribed in patients with vitiligo. However, they are often not effective and safe (epidermal atrophy). Therefore, research for alternative therapies continues. Aims: To evaluate the beneficial effects of a supplementation with antioxidant vitamins (A, C, E) and minerals (zinc, selenium) for vitiligo treatment. Methods: Forty experimental autoimmune vitiligo mice C57BL6, aged from 5 to 12 months showing visible signs of induced vitiligo, were sequentially randomized into five parallel groups (8 mice per group). Each group mice was allocated an identical pre coded cage. the first group (SZV) received the ED+1,4 g zinc (Zn)+0.04 g selenium (Se)+vitamins (A 118 UI, C 8,5 mg, E 5,4 UI) /kg diet, the second group (PSZV) received the ED+1,4 g zinc (Zn)+0.04 g selenium (Se)+vitamins (A 118 UI, C 8.5 mg, E 5,4 UI)/kg diet+Polyphenol orally, the group 3 (PSZ ) received the ED+green tea decoction prepared from 100 g/l (polyphenol orally)+1,4 g Zn+0.04 g Se, the 4 (P) received the ED+green tea decoction prepared green tea decoction prepared from 100 g/l, the control group 5(C) received the ED++ distilled water. Cure was defined as repigmentation of treated sites. Photographic and optical techniques were used both at the baseline and on weekly basis. Results: By the end of the study, mices showed visible repigmentation. Using the investigator's global assessment, therapeutic success in terms of a clear repigmentation documented in 70% of treated mice. Conclusion: Our findings suggest that an antioxidant supplementation is significantly beneficial in contributing superior clinical efficacy to cure vitiligo.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed7738    
    Printed190    
    Emailed2    
    PDF Downloaded2286    
    Comments [Add]    
    Cited by others 3    

Recommend this journal