Indian Journal of Dermatology
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ORIGINAL ARTICLE
Year : 2009  |  Volume : 54  |  Issue : 4  |  Page : 334-337

Familial reactive perforating collagenosis


1 Departments of Dermatology, STD & Leprosy and Pathology, SKIMS Medical, College Hospital, Srinagar, India
2 Departments of Dermatology, STD & Leprosy and Pathology, SKIMS Soura, Srinagar, India

Correspondence Address:
Yasmeen J Bhat
Department of Dermatology, STD & Leprosy, SKIMS MCH Srinagar
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5154.57608

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Background: Reactive perforating collagenosis (RPC) is one of the rare forms of transepidermal elimination in which genetically altered collagen is extruded from the epidermis. This disease usually starts in early childhood as asymptomatic umbilicated papules on extremities, and the lesions become more conspicuous with age. Aims: The objective of our study was to determine the clinico-pathological features of RPC and the response to various treatment modalities. Methods: Ten patients of RPC, belonging to five different families, were studied clinically. Various laboratory investigations were carried out and diagnosis was made by histopathology of the lesions. Patients were given various topical and oral treatments. Results: RPC is familial in most cases without any definite inheritance pattern. It begins in childhood and the lesions are usually recurrent and become profuse and large with age. Systemic diseases have no role in the onset of lesions. Conclusion: Oral and topical retinoids in combination with emollients is the best treatment option.


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