Indian Journal of Dermatology
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BASIC RESEARCH
Year : 2009  |  Volume : 54  |  Issue : 4  |  Page : 323-329

Photo-stimulatory effect of low energy helium-neon laser irradiation on excisional diabetic wound healing dynamics in wistar rats


Department of Physiotherapy, Manipal Medical College, Manipal, India

Correspondence Address:
Arun G Maiya
Department of Physiotherapy, Manipal University, Manipal - 576 104
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5154.57606

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Background: Generally, the significances of laser photo stimulation are now accepted, but the laser light facilitates wound healing and tissue repair remains poorly understood. Aims: We have examined the hypothesis that the laser photo stimulation can enhance the collagen production in diabetic wounds using the excision wound model in the Wistar rat model. Methods: The circular wounds were created on the dorsum of the back of the animals. The animals were divided into two groups. The study group (N = 24) wound was treated with 632.8 nm He-Ne laser at a dose of 3-9J/cm 2 for 5 days a week until the wounds healed completely. The control group was sham irradiated. Result: A significant increase in the hydroxyproline content and reduction in the wound size were observed in the study group. The pro-healing actions seem to be due to increased collagen deposition as well as better alignment and maturation. Conclusion: The biochemical analysis and clinical observation suggested that 3-6 J/cm 2 laser photo stimulation facilitates the tissue repair process by accelerating collagen production in diabetic wound healing.


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